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Role of hypoxia-induced exosomes in tumor biology
Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology. The relevant publications were retrieved from PubMed using keywords such as hypoxia, ex...
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| Published in: | Molecular cancer 2018-08, Vol.17 (1), p.120-120, Article 120 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c560t-e57070372e74be98f7bebc198d662adf10a72cec96e931f6d73c18ccc50bbc73 |
| container_end_page | 120 |
| container_issue | 1 |
| container_start_page | 120 |
| container_title | Molecular cancer |
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| creator | Shao, Chuchu Yang, Fengming Miao, Suyu Liu, Weitao Wang, Chaoshan Shu, Yongqian Shen, Hua |
| description | Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology.
The relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, and other similar terms.
Recent studies have shown that cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. The secretion and function of exosomes could be influenced by hypoxia in various types of cancer. Hypoxia-induced exosomes play critical roles in tumor angiogenesis, invasion, metastasis, and the immune system.
These findings provide new insights into the complex networks underlying cellular and genomic regulation in response to hypoxia and might provide novel and specific targets for future therapies. |
| doi_str_mv | 10.1186/s12943-018-0869-y |
| format | article |
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The relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, and other similar terms.
Recent studies have shown that cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. The secretion and function of exosomes could be influenced by hypoxia in various types of cancer. Hypoxia-induced exosomes play critical roles in tumor angiogenesis, invasion, metastasis, and the immune system.
These findings provide new insights into the complex networks underlying cellular and genomic regulation in response to hypoxia and might provide novel and specific targets for future therapies.</description><identifier>ISSN: 1476-4598</identifier><identifier>EISSN: 1476-4598</identifier><identifier>DOI: 10.1186/s12943-018-0869-y</identifier><identifier>PMID: 30098600</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Angiogenesis ; Apoptosis ; Biology ; Body fluids ; Brain tumors ; Breast cancer ; Cancer ; Cell Hypoxia ; Communication ; Exosome ; Exosomes ; Exosomes - metabolism ; Extracellular vesicles ; Gene expression ; Growth factors ; Health aspects ; Humans ; Hypoxia ; Hypoxia (Aquatic ecology) ; Immune system ; Metastases ; Metastasis ; MicroRNAs ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasms - metabolism ; Neovascularization ; Neovascularization, Pathologic - metabolism ; Review ; Secretion ; Tumors</subject><ispartof>Molecular cancer, 2018-08, Vol.17 (1), p.120-120, Article 120</ispartof><rights>COPYRIGHT 2018 BioMed Central Ltd.</rights><rights>Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-e57070372e74be98f7bebc198d662adf10a72cec96e931f6d73c18ccc50bbc73</citedby><cites>FETCH-LOGICAL-c560t-e57070372e74be98f7bebc198d662adf10a72cec96e931f6d73c18ccc50bbc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087002/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2089858258?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30098600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shao, Chuchu</creatorcontrib><creatorcontrib>Yang, Fengming</creatorcontrib><creatorcontrib>Miao, Suyu</creatorcontrib><creatorcontrib>Liu, Weitao</creatorcontrib><creatorcontrib>Wang, Chaoshan</creatorcontrib><creatorcontrib>Shu, Yongqian</creatorcontrib><creatorcontrib>Shen, Hua</creatorcontrib><title>Role of hypoxia-induced exosomes in tumor biology</title><title>Molecular cancer</title><addtitle>Mol Cancer</addtitle><description>Hypoxia is a major regulator of angiogenesis and always influences the release of exosomes in various types of tumors. The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology.
The relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, and other similar terms.
Recent studies have shown that cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. The secretion and function of exosomes could be influenced by hypoxia in various types of cancer. Hypoxia-induced exosomes play critical roles in tumor angiogenesis, invasion, metastasis, and the immune system.
These findings provide new insights into the complex networks underlying cellular and genomic regulation in response to hypoxia and might provide novel and specific targets for future therapies.</description><subject>Analysis</subject><subject>Angiogenesis</subject><subject>Apoptosis</subject><subject>Biology</subject><subject>Body fluids</subject><subject>Brain tumors</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cell Hypoxia</subject><subject>Communication</subject><subject>Exosome</subject><subject>Exosomes</subject><subject>Exosomes - metabolism</subject><subject>Extracellular vesicles</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia (Aquatic ecology)</subject><subject>Immune system</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>MicroRNAs</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasms - metabolism</subject><subject>Neovascularization</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Review</subject><subject>Secretion</subject><subject>Tumors</subject><issn>1476-4598</issn><issn>1476-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkktr3DAUhUVpadK0P6CbYuimG6dXlqzHphBCH4FAoWQvJPl6osG2ppJd4n8fTSdNM6VoIXH1nXO50iHkLYVzSpX4mGmjOauBqhqU0PX6jJxSLkXNW62ePzmfkFc5bwGoVJK_JCcMQCsBcErojzhgFfvqdt3Fu2DrMHWLx67Cu5jjiLkKUzUvY0yVC3GIm_U1edHbIeObh_2M3Hz5fHP5rb7-_vXq8uK69q2AucZWggQmG5TcoVa9dOg81aoTorFdT8HKxqPXAjWjvegk81R571twzkt2Rq4Otl20W7NLYbRpNdEG87sQ08bYNAc_oMGOW9U4KSRy3jrpqJKqNPJSgXeWFa9PB6_d4kbsPE5zssOR6fHNFG7NJv4yApQEaIrBhweDFH8umGczhuxxGOyEccmmKZzWjFFe0Pf_oNu4pKm81J7SqlVNq_5SG1sGCFMfS1-_NzUXLS9_Q7loC3X-H6qsDsfg44R9KPUjAT0IfIo5J-wfZ6Rg9pExh8iYEhmzj4xZi-bd08d5VPzJCLsH41S7Dg</recordid><startdate>20180811</startdate><enddate>20180811</enddate><creator>Shao, Chuchu</creator><creator>Yang, Fengming</creator><creator>Miao, Suyu</creator><creator>Liu, Weitao</creator><creator>Wang, Chaoshan</creator><creator>Shu, Yongqian</creator><creator>Shen, Hua</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20180811</creationdate><title>Role of hypoxia-induced exosomes in tumor biology</title><author>Shao, Chuchu ; 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The present review aimed to assess the role of hypoxia-induced exosomes in the tumor biology.
The relevant publications were retrieved from PubMed using keywords such as hypoxia, exosome, extracellular vesicles, tumor, cancer, and other similar terms.
Recent studies have shown that cancer cells produce more exosomes under hypoxic conditions than do parental cells under normoxic conditions. The secretion and function of exosomes could be influenced by hypoxia in various types of cancer. Hypoxia-induced exosomes play critical roles in tumor angiogenesis, invasion, metastasis, and the immune system.
These findings provide new insights into the complex networks underlying cellular and genomic regulation in response to hypoxia and might provide novel and specific targets for future therapies.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>30098600</pmid><doi>10.1186/s12943-018-0869-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Angiogenesis Apoptosis Biology Body fluids Brain tumors Breast cancer Cancer Cell Hypoxia Communication Exosome Exosomes Exosomes - metabolism Extracellular vesicles Gene expression Growth factors Health aspects Humans Hypoxia Hypoxia (Aquatic ecology) Immune system Metastases Metastasis MicroRNAs Neoplasm Invasiveness Neoplasm Metastasis Neoplasms - metabolism Neovascularization Neovascularization, Pathologic - metabolism Review Secretion Tumors |
| title | Role of hypoxia-induced exosomes in tumor biology |
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