Bioprosthesis in aortic valve replacement: long-term inflammatory response and functionality

BackgroundThe evaluation of long-term inflammatory response and function in postoperative patients with aortic valve replacement (AVR) deserves special analysis because it is important to try to prevent reoperation and improve durability and functionality of the prostheses. It is our objectiveMethod...

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Published in:Open heart 2022-08, Vol.9 (2), p.e002065
Main Authors: Saucedo-Orozco, Huitzilihuitl, Vargas-Barron, Jesus, Márquez-Velazco, Ricardo, Farjat-Pasos, Julio Iván, Martinez-Zavala, Karla Susana, Jiménez-Rojas, Valentin, Criales-Vera, Sergio Andres, Arias-Godínez, Jose Antonio, Fuentevilla-Alvarez, Giovanni, Guarner-Lans, Veronica, Perez-Torres, Israel, Melendez-Ramirez, Gabriela, Sanchez Perez, Tomas Efrain, Soto, Maria Elena
Format: Article
Language:English
Subjects:
Age
Aortic Valve Insufficiency
Aortic Valve Stenosis
Biomarkers
Body mass index
Cardiovascular disease
Consent
Cytokines
Echocardiography
Gender
Heart Valve Prosthesis
High density lipoprotein
Phlebotomy
Prostheses
Pulmonary arteries
Survival analysis
Tumor necrosis factor-TNF
Valvular Heart Disease
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Summary:BackgroundThe evaluation of long-term inflammatory response and function in postoperative patients with aortic valve replacement (AVR) deserves special analysis because it is important to try to prevent reoperation and improve durability and functionality of the prostheses. It is our objectiveMethodsIn this study, we included a cohort of patients with aortic valve damage treated by AVR with mechanical prosthesis, bio prosthesis and we included a control group.ResultsWe found that IL-4 and osteopontin levels were higher in patients with mechanical vs biological prostheses (p=0.01 and p=0.04, respectively), osteoprotegerin (OPG) levels were decreased (p=0.01), women had lower levels of ET-1 and IL-6, (p=0.02) (p=0.04), respectively. Patients older than 60 years had decreased levels of IL-1ß p
ISSN:2053-3624
2398-595X
2053-3624
DOI:10.1136/openhrt-2022-002065