Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats

Previous experiments in animals and humans show that shifts in microbiota and its metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX, a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and attenuate hypertension...

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Bibliographic Details
Published in:Nutrients 2021-08, Vol.13 (9), p.2971
Main Authors: Robles-Vera, Iñaki, de la Visitación, Néstor, Toral, Marta, Sánchez, Manuel, Romero, Miguel, Gómez-Guzmán, Manuel, Vargas, Félix, Duarte, Juan, Jiménez, Rosario
Format: Article
Language:English
Subjects:
Acetic acid
Animal models
Antibiotics
Aorta
Blood pressure
Cardiovascular pathology
Coronary vessels
DOCA-salt model
Doxycycline
Drinking water
Dysbacteriosis
Endothelium
Endotoxemia
gut dysbiosis
Hypertension
Immunomodulation
Inflammation
Intestinal microflora
Laboratory animals
Lactic acid
Lymphocytes T
Metabolites
Microbiota
Microorganisms
Nitric oxide
Noradrenaline
Norepinephrine
Oxidative stress
Plasma
Polymerase chain reaction
Renin
Salt
Salts
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Summary:Previous experiments in animals and humans show that shifts in microbiota and its metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX, a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model of hypertension. Male Wistar rats were randomly assigned to three groups: control, DOCA-salt hypertensive rats, DOCA-salt treated with DOX for 4 weeks. DOX decreased systolic blood pressure, improving endothelial dysfunction and reducing aortic oxidative stress and inflammation. DOX decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier integrity, normalized endotoxemia, plasma noradrenaline levels and restored the Treg content in aorta. These data demonstrate that DOX through direct effects on gut microbiota and its non-microbial effects (anti-inflammatory and immunomodulatory) reduces endothelial dysfunction and the increase in blood pressure in this low-renin form of hypertension.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13092971