The Impact of Prolonged Mechanical Ventilation on Overall Survival in Patients With Surgically Treated Brain Metastases

Surgical resection represents a common treatment modality in patients with brain metastasis (BM). Postoperative prolonged mechanical ventilation (PMV) might have an enormous impact on the overall survival (OS) of these patients suffering from advanced cancer disease. We therefore have analyzed our i...

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Bibliographic Details
Published in:Frontiers in oncology 2021-03, Vol.11, p.658949-658949
Main Authors: Schuss, Patrick, Schäfer, Niklas, Bode, Christian, Borger, Valeri, Eichhorn, Lars, Giordano, Frank A, Güresir, Erdem, Heimann, Muriel, Ko, Yon-Dschun, Landsberg, Jennifer, Lehmann, Felix, Potthoff, Anna-Laura, Radbruch, Alexander, Schaub, Christina, Schwab, Katjana S, Weller, Johannes, Vatter, Hartmut, Herrlinger, Ulrich, Schneider, Matthias
Format: Article
Language:English
Subjects:
brain metastases
cancer
intensive care
Oncology
overall survival
prolonged mechanical ventilation
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Summary:Surgical resection represents a common treatment modality in patients with brain metastasis (BM). Postoperative prolonged mechanical ventilation (PMV) might have an enormous impact on the overall survival (OS) of these patients suffering from advanced cancer disease. We therefore have analyzed our institutional database with regard to a potential impact of PMV on OS of patients who had undergone surgery for brain metastases. 360 patients with surgically treated brain metastases were included. The definition of PMV consisted of postoperative mechanical ventilation lasting for more than 48 hours. Analysis of survival incorporating established prognostic factors such as age, location of BM, and preoperative physical status was performed. 14 of 360 patients with BM (4%) suffered from postoperative PMV after surgical treatment of BM. Patients with PMV presented in a significantly more impaired neurological condition preoperatively than patients without (p
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.658949