Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study

Some studies have shown that gut microbiota may be associated with dementia. However, the causal effects between gut microbiota and different types of dementia and whether cytokines act as a mediator remain unclear. Gut microbiota, cytokines, and five dementia types, including Alzheimer's disea...

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Bibliographic Details
Published in:Journal of neuroinflammation 2024-01, Vol.21 (1), p.2-2, Article 2
Main Authors: Ji, Dong, Chen, Wen-Zhu, Zhang, Lei, Zhang, Zhi-Hua, Chen, Li-Jian
Format: Article
Language:English
Subjects:
Alzheimer's disease
Causality
Cognitive ability
Confounding (Statistics)
Consortia
Cytokines
Dementia
Dementia disorders
Diagnosis
Disease
Frontotemporal dementia
Genetic aspects
Genome-wide association studies
Genomes
Gut microbiota
Health aspects
Intestinal microflora
Lewy bodies
Mendelian randomization
Microbiota
Microbiota (Symbiotic organisms)
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Physiological aspects
Risk factors
Sexually transmitted diseases
Statistical power
STD
Vascular dementia
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Summary:Some studies have shown that gut microbiota may be associated with dementia. However, the causal effects between gut microbiota and different types of dementia and whether cytokines act as a mediator remain unclear. Gut microbiota, cytokines, and five dementia types, including Alzheimer's disease (AD), frontotemporal dementia (FTD), dementia with Lewy body (DLB), vascular dementia (VD), and Parkinson's disease dementia (PDD) were identified from large-scale genome-wide association studies (GWAS) summary data. We used Mendelian randomization (MR) to investigate the causal relationships between gut microbiota, cytokines, and five types of dementia. Inverse variance weighting (IVW) was used as the main statistical method. In addition, we explored whether cytokines act as a mediating factor in the pathway from gut microbiota to dementia. There were 20 positive and 16 negative causal effects between genetic liability in the gut microbiota and dementia. Also, there were five positive and four negative causal effects between cytokines and dementias. Cytokines did not act as mediating factors. Gut microbiota and cytokines were causally associated with five types of dementia, and cytokines seemed not to be the mediating factors in the pathway from gut microbiota to dementia.
ISSN:1742-2094
1742-2094
DOI:10.1186/s12974-023-02999-0