Hemoglobin concentration, total hemoglobin mass and plasma volume in patients: implications for anemia

In practice, clinicians generally consider anemia (circulating hemoglobin concentration < 120 g.l in non-pregnant females and < 130 g.l in males) as due to impaired hemoglobin synthesis or increased erythrocyte loss or destruction. Rarely is a rise in plasma volume relative to circulating tota...

Full description

Saved in:
Bibliographic Details
Published in:Haematologica (Roma) 2017-09, Vol.102 (9), p.1477-1485
Main Authors: Otto, James M, Plumb, James O M, Clissold, Eleri, Kumar, Shriya B, Wakeham, Denis J, Schmidt, Walter, Grocott, Michael P W, Richards, Toby, Montgomery, Hugh E
Format: Article
Language:English
Subjects:
Adult
Anemia - blood
Anemia - physiopathology
Female
Heart Failure - blood
Heart Failure - physiopathology
Hemoglobins - metabolism
Humans
Male
Middle Aged
Plasma Volume
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In practice, clinicians generally consider anemia (circulating hemoglobin concentration < 120 g.l in non-pregnant females and < 130 g.l in males) as due to impaired hemoglobin synthesis or increased erythrocyte loss or destruction. Rarely is a rise in plasma volume relative to circulating total hemoglobin mass considered as a cause. But does this matter? We explored this issue in patients, measuring hemoglobin concentration, total hemoglobin mass (optimized carbon monoxide rebreathing method) and thereby calculating plasma volume in healthy volunteers, surgical patients, and those with inflammatory bowel disease, chronic liver disease or heart failure. We studied 109 participants. Hemoglobin mass correlated well with its concentration in the healthy, surgical and inflammatory bowel disease groups (r=0.687-0.871,
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.2017.169680