Serum spexin concentration, body condition score and markers of obesity in dogs

Background Spexin (SPX) is a peptide hormone that regulates body weight, adipose tissue metabolism, and food intake. Hypothesis Serum SPX concentration correlates with body condition score (BCS) and markers of obesity in dogs. Animals Fifty‐seven dogs of varying body condition assessed using a 5‐poi...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2021-01, Vol.35 (1), p.397-404
Main Authors: Kolodziejski, Pawel Antoni, Pruszynska‐Oszmalek, Ewa, Nowak, Tomasz, Lukomska, Anna, Sassek, Maciej, Wlodarek, Jan, Nogowski, Leszek, Cieslak, Adam, Nowak, Krzysztof W.
Format: Article
Language:English
Subjects:
Age
Animals
BCS
Body fat
Cholesterol
Dehydrogenases
Dogs
Fatty acids
Gene expression
hormones
insulin
Laboratories
metabolism
Obesity
Overweight
Peptides
Polymerase chain reaction
SMALL ANIMAL
Triglycerides
Variables
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Summary:Background Spexin (SPX) is a peptide hormone that regulates body weight, adipose tissue metabolism, and food intake. Hypothesis Serum SPX concentration correlates with body condition score (BCS) and markers of obesity in dogs. Animals Fifty‐seven dogs of varying body condition assessed using a 5‐point BCS. Methods Prospective, nonblinded, observational cohort study. Serum SPX concentration was measured using commercially available radioimmunoassay (RIA) in dogs with varying BCS. Spexin mRNA and protein expression were detected using real‐time quantitative polymerase chain reaction and immunofluorescence staining. Results Serum SPX concentration was lower in dogs with BCS4 (8.56 +/‐ 2.86) and BCS5 (6.7 +/‐ 2.12) compared to BCS2 (11.96 +/‐ 2.23) and BCS3 (10.51 +/‐ 2.19; BCS2 vs BCS5, P 
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.16019