Serologic evidence of widespread Toscana virus infection in Bulgaria

• Published in: Journal of infection and public health 2020-02, Vol.13 (2), p.164-166
• Main Authors: Christova, Iva, Panayotova, Elitsa, Trifonova, Iva, Taseva, Evgenia, Gladnishka, Teodora, Ivanova, Vladislava
• Format: Article
• Language: English
• Subjects: Bulgaria; Phlebovirus; Sandfly-borne infection; Toscana virus
• ISSN: 1876-0341; 1876-035X
• DOI: 10.1016/j.jiph.2019.07.008

•The first TOSV seroprevalence study in Bulgaria revealed that the virus is wide-spread in the country.•TOSV IgG antibodies were detected in 24.4% of Bulgarian healthy population.•Age over 60 years and residency in the southern districts were identified as risk factors.•The districts in southern Bulgaria together with the prefectures in northern Greece should be considered as endemic for TOSV infections. Toscana virus (TOSV) is an emerging sandfly-borne virus that is endemic in Mediterranean countries. In order to detect TOSV circulation among the human population of Bulgaria, serum samples from 459 apparently healthy adult individuals, residing in19 out of 28 districts in the country, were tested for the presence of IgG antibodies to TOSV. An overall seroprevalence rate of 24.4% was observed, ranging from 4.4% to 53.5% in the districts. Rates were highest in persons over 60 years of age and residing in the southern districts. The results of the first TOSV seroprevalence study in Bulgaria revealed that infection is widespread. Physicians should be aware of the virus circulation during summer and consider the diagnosis in cases of febrile illness, meningitis or meningoencephalitis.