Focal Idiopathic Hypertrophic Pachymeningoencephalitis

Cranial pachymeningitis is typically a diffuse granulomatous disease that involves the dura mater extensively without intra-axial involvement. We report a rare case of focal idiopathic hypertrophic pachymenin-goencephalitis (IHP) focally affecting the right parietal dura mater and adjacent parietal...

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Bibliographic Details
Published in:Journal of the Formosan Medical Association 2008-02, Vol.107 (2), p.181-184
Main Authors: Lu, Yun-Ru, Yeh, Jiann-Horng, Tsai, Min-Der, Lee, Chin-Cheng, Chen, Wei-Hung
Format: Article
Language:English
Subjects:
Adult
chronic inflammation
Dura Mater - pathology
Humans
Hypertrophy
Internal Medicine
Male
meningoencephalitis
Meningoencephalitis - diagnosis
Meningoencephalitis - pathology
Meningoencephalitis - physiopathology
pachymeningitis
Parietal Lobe - pathology
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Summary:Cranial pachymeningitis is typically a diffuse granulomatous disease that involves the dura mater extensively without intra-axial involvement. We report a rare case of focal idiopathic hypertrophic pachymenin-goencephalitis (IHP) focally affecting the right parietal dura mater and adjacent parietal lobule. A 43-year-old male suffered from acute onset of rhythmic twitching over the left abdominal muscles that had persisted for more than 4 hours. Neurologic examination revealed mild weakness and impaired sensation in the left lower limb. Electroencephalography disclosed active focal spikes in the right parietal region and brain magnetic resonance imaging showed a well-enhanced lesion involving the right parietal lobe and its overlying dura mater. Surgical removal of the lesion revealed infiltration by abundant chronic inflammatory cells without granuloma formation, caseous necrosis or vasculitis. After surgery, the patient was treated with steroid, which was tapered off 5 months later. Serial magnetic resonance imaging follow-up revealed that the parenchymal mass and perifocal edema had completely disappeared 6 months after the operation. We suggest that early recognition of this rare IHP, together with proper surgical intervention and concomitant steroid therapy, may be beneficial for long-term remission.
ISSN:0929-6646
DOI:10.1016/S0929-6646(08)60132-1