L. rhamnosus improves the immune response and tryptophan catabolism in laying hen pullets

In mammals, early-life probiotic supplementation is a promising tool for preventing unfavourable, gut microbiome-related behavioural, immunological, and aromatic amino acid alterations later in life. In laying hens, feather-pecking behaviour is proposed to be a consequence of gut-brain axis dysregul...

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Bibliographic Details
Published in:Scientific reports 2021-10, Vol.11 (1), p.19538-19538, Article 19538
Main Authors: Mindus, Claire, van Staaveren, Nienke, Fuchs, Dietmar, Gostner, Johanna M., Kjaer, Joergen B., Kunze, Wolfgang, Mian, M. Firoz, Shoveller, Anna K., Forsythe, Paul, Harlander-Matauschek, Alexandra
Format: Article
Language:English
Subjects:
631/601/1737
631/601/18
Age
Age Factors
Amino acids
Animals
Behavior, Animal
Biomarkers
Birds
Chickens
Cytotoxicity
Dietary supplements
Feathers
Genetic Association Studies
Genetic Background
Host Microbial Interactions
Humanities and Social Sciences
Immune response
Immune system
Immunity
Intestinal microflora
Lacticaseibacillus rhamnosus - physiology
Lactobacillus rhamnosus
Long-term effects
Lymphocytes
Lymphocytes T
Microbiomes
Microbiota
multidisciplinary
Pecking behavior
Probiotics
Quantitative Trait, Heritable
Science
Science (multidisciplinary)
Serotonin
Stress, Physiological - immunology
Tryptophan
Tryptophan - blood
Tryptophan - metabolism
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Summary:In mammals, early-life probiotic supplementation is a promising tool for preventing unfavourable, gut microbiome-related behavioural, immunological, and aromatic amino acid alterations later in life. In laying hens, feather-pecking behaviour is proposed to be a consequence of gut-brain axis dysregulation. Lactobacillus rhamnosus decreases stress-induced severe feather pecking in adult hens, but whether its effect in pullets is more robust is unknown. Consequently, we investigated whether early-life, oral supplementation with a single Lactobacillus rhamnosus strain can prevent stress-induced feather-pecking behaviour in chickens. To this end, we monitored both the short- and long-term effects of the probiotic supplement on behaviour and related physiological parameters. We hypothesized that L. rhamnosus would reduce pecking behaviour by modulating the biological pathways associated with this detrimental behaviour, namely aromatic amino acid turnover linked to neurotransmitter production and stress-related immune responses. We report that stress decreased the proportion of cytotoxic T cells in the tonsils (P = 0.047). Counteracting this T cell depression, birds receiving the L. rhamnosus supplementation significantly increased all T lymphocyte subset proportions (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-98459-x