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L. rhamnosus improves the immune response and tryptophan catabolism in laying hen pullets
In mammals, early-life probiotic supplementation is a promising tool for preventing unfavourable, gut microbiome-related behavioural, immunological, and aromatic amino acid alterations later in life. In laying hens, feather-pecking behaviour is proposed to be a consequence of gut-brain axis dysregul...
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| Published in: | Scientific reports 2021-10, Vol.11 (1), p.19538-19538, Article 19538 |
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| creator | Mindus, Claire van Staaveren, Nienke Fuchs, Dietmar Gostner, Johanna M. Kjaer, Joergen B. Kunze, Wolfgang Mian, M. Firoz Shoveller, Anna K. Forsythe, Paul Harlander-Matauschek, Alexandra |
| description | In mammals, early-life probiotic supplementation is a promising tool for preventing unfavourable, gut microbiome-related behavioural, immunological, and aromatic amino acid alterations later in life. In laying hens, feather-pecking behaviour is proposed to be a consequence of gut-brain axis dysregulation.
Lactobacillus rhamnosus
decreases stress-induced severe feather pecking in adult hens, but whether its effect in pullets is more robust is unknown. Consequently, we investigated whether early-life, oral supplementation with a single
Lactobacillus rhamnosus
strain can prevent stress-induced feather-pecking behaviour in chickens. To this end, we monitored both the short- and long-term effects of the probiotic supplement on behaviour and related physiological parameters. We hypothesized that
L. rhamnosus
would reduce pecking behaviour by modulating the biological pathways associated with this detrimental behaviour, namely aromatic amino acid turnover linked to neurotransmitter production and stress-related immune responses. We report that stress decreased the proportion of cytotoxic T cells in the tonsils (P = 0.047). Counteracting this T cell depression, birds receiving the
L. rhamnosus
supplementation significantly increased all T lymphocyte subset proportions (P |
| doi_str_mv | 10.1038/s41598-021-98459-x |
| format | article |
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Lactobacillus rhamnosus
decreases stress-induced severe feather pecking in adult hens, but whether its effect in pullets is more robust is unknown. Consequently, we investigated whether early-life, oral supplementation with a single
Lactobacillus rhamnosus
strain can prevent stress-induced feather-pecking behaviour in chickens. To this end, we monitored both the short- and long-term effects of the probiotic supplement on behaviour and related physiological parameters. We hypothesized that
L. rhamnosus
would reduce pecking behaviour by modulating the biological pathways associated with this detrimental behaviour, namely aromatic amino acid turnover linked to neurotransmitter production and stress-related immune responses. We report that stress decreased the proportion of cytotoxic T cells in the tonsils (P = 0.047). Counteracting this T cell depression, birds receiving the
L. rhamnosus
supplementation significantly increased all T lymphocyte subset proportions (P < 0.05). Both phenotypic and genotypic feather peckers had lower plasma tryptophan concentrations compared to their non-pecking counterparts. The probiotic supplement caused a short-term increase in plasma tryptophan (P < 0.001) and the TRP:(PHE + TYR) ratio (P < 0.001). The administration of stressors did not significantly increase feather pecking in pullets, an observation consistent with the age-dependent onset of pecking behaviour. Despite minimal changes to behaviour, our data demonstrate the impact of
L. rhamnosus
supplementation on the immune system and the turnover of the serotonin precursor tryptophan. Our findings indicate that
L. rhamnosus
exerts a transient, beneficial effect on the immune response and tryptophan catabolism in pullets.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-98459-x</identifier><identifier>PMID: 34599202</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/601/1737 ; 631/601/18 ; Age ; Age Factors ; Amino acids ; Animals ; Behavior, Animal ; Biomarkers ; Birds ; Chickens ; Cytotoxicity ; Dietary supplements ; Feathers ; Genetic Association Studies ; Genetic Background ; Host Microbial Interactions ; Humanities and Social Sciences ; Immune response ; Immune system ; Immunity ; Intestinal microflora ; Lacticaseibacillus rhamnosus - physiology ; Lactobacillus rhamnosus ; Long-term effects ; Lymphocytes ; Lymphocytes T ; Microbiomes ; Microbiota ; multidisciplinary ; Pecking behavior ; Probiotics ; Quantitative Trait, Heritable ; Science ; Science (multidisciplinary) ; Serotonin ; Stress, Physiological - immunology ; Tryptophan ; Tryptophan - blood ; Tryptophan - metabolism</subject><ispartof>Scientific reports, 2021-10, Vol.11 (1), p.19538-19538, Article 19538</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-3b2c12d3f457ced3b738acec54fe0a52eaab3f1343444159c4ad0e05b42ab16e3</citedby><cites>FETCH-LOGICAL-c606t-3b2c12d3f457ced3b738acec54fe0a52eaab3f1343444159c4ad0e05b42ab16e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2578267934/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2578267934?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53769,53771,74872</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34599202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mindus, Claire</creatorcontrib><creatorcontrib>van Staaveren, Nienke</creatorcontrib><creatorcontrib>Fuchs, Dietmar</creatorcontrib><creatorcontrib>Gostner, Johanna M.</creatorcontrib><creatorcontrib>Kjaer, Joergen B.</creatorcontrib><creatorcontrib>Kunze, Wolfgang</creatorcontrib><creatorcontrib>Mian, M. Firoz</creatorcontrib><creatorcontrib>Shoveller, Anna K.</creatorcontrib><creatorcontrib>Forsythe, Paul</creatorcontrib><creatorcontrib>Harlander-Matauschek, Alexandra</creatorcontrib><title>L. rhamnosus improves the immune response and tryptophan catabolism in laying hen pullets</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>In mammals, early-life probiotic supplementation is a promising tool for preventing unfavourable, gut microbiome-related behavioural, immunological, and aromatic amino acid alterations later in life. In laying hens, feather-pecking behaviour is proposed to be a consequence of gut-brain axis dysregulation.
Lactobacillus rhamnosus
decreases stress-induced severe feather pecking in adult hens, but whether its effect in pullets is more robust is unknown. Consequently, we investigated whether early-life, oral supplementation with a single
Lactobacillus rhamnosus
strain can prevent stress-induced feather-pecking behaviour in chickens. To this end, we monitored both the short- and long-term effects of the probiotic supplement on behaviour and related physiological parameters. We hypothesized that
L. rhamnosus
would reduce pecking behaviour by modulating the biological pathways associated with this detrimental behaviour, namely aromatic amino acid turnover linked to neurotransmitter production and stress-related immune responses. We report that stress decreased the proportion of cytotoxic T cells in the tonsils (P = 0.047). Counteracting this T cell depression, birds receiving the
L. rhamnosus
supplementation significantly increased all T lymphocyte subset proportions (P < 0.05). Both phenotypic and genotypic feather peckers had lower plasma tryptophan concentrations compared to their non-pecking counterparts. The probiotic supplement caused a short-term increase in plasma tryptophan (P < 0.001) and the TRP:(PHE + TYR) ratio (P < 0.001). The administration of stressors did not significantly increase feather pecking in pullets, an observation consistent with the age-dependent onset of pecking behaviour. Despite minimal changes to behaviour, our data demonstrate the impact of
L. rhamnosus
supplementation on the immune system and the turnover of the serotonin precursor tryptophan. Our findings indicate that
L. rhamnosus
exerts a transient, beneficial effect on the immune response and tryptophan catabolism in pullets.</description><subject>631/601/1737</subject><subject>631/601/18</subject><subject>Age</subject><subject>Age Factors</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Biomarkers</subject><subject>Birds</subject><subject>Chickens</subject><subject>Cytotoxicity</subject><subject>Dietary supplements</subject><subject>Feathers</subject><subject>Genetic Association Studies</subject><subject>Genetic Background</subject><subject>Host Microbial Interactions</subject><subject>Humanities and Social Sciences</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Intestinal microflora</subject><subject>Lacticaseibacillus rhamnosus - physiology</subject><subject>Lactobacillus rhamnosus</subject><subject>Long-term effects</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>multidisciplinary</subject><subject>Pecking behavior</subject><subject>Probiotics</subject><subject>Quantitative Trait, Heritable</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Serotonin</subject><subject>Stress, Physiological - immunology</subject><subject>Tryptophan</subject><subject>Tryptophan - blood</subject><subject>Tryptophan - metabolism</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1v1DAQhiMEotXSP8ABWeLCJcWfiX1BQhUflVbiAgdO1sSZ7GaV2MFOqu6_x92U0nLAF3_MO8947LcoXjN6yajQ75NkyuiSclYaLZUpb58V55xKVXLB-fNH67PiIqUDzUNxI5l5WZyJnGA45efFz-0liXsYfUhLIv04xXCDicx7zJtx8Ugipin4hAR8S-Z4nOYw7cETBzM0YejTSHpPBjj2fkf26Mm0DAPO6VXxooMh4cX9vCl-fP70_epruf325frq47Z0Fa3mUjTcMd6KTqraYSuaWmhw6JTskILiCNCIjgkppLxr2UloKVLVSA4Nq1BsiuuV2wY42Cn2I8SjDdDb00GIOwtx7t2AtmOaC8OAihqkcGhk03aCMdV0CivDM-vDypqWZsTWoZ8jDE-gTyO-39tduLFa6kprlgHv7gEx_FowzXbsk8NhAI9hSZarWteV4Kdab_-RHsISfX6qk4pXtclNbwq-qlwMKUXsHi7DqL0zgl2NYLMR7MkI9jYnvXncxkPKn2_PArEKUg75Hca_tf-D_Q3vscBE</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Mindus, Claire</creator><creator>van Staaveren, Nienke</creator><creator>Fuchs, Dietmar</creator><creator>Gostner, Johanna M.</creator><creator>Kjaer, Joergen B.</creator><creator>Kunze, Wolfgang</creator><creator>Mian, M. 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Firoz ; Shoveller, Anna K. ; Forsythe, Paul ; Harlander-Matauschek, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-3b2c12d3f457ced3b738acec54fe0a52eaab3f1343444159c4ad0e05b42ab16e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/601/1737</topic><topic>631/601/18</topic><topic>Age</topic><topic>Age Factors</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Biomarkers</topic><topic>Birds</topic><topic>Chickens</topic><topic>Cytotoxicity</topic><topic>Dietary supplements</topic><topic>Feathers</topic><topic>Genetic Association Studies</topic><topic>Genetic Background</topic><topic>Host Microbial Interactions</topic><topic>Humanities and Social Sciences</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Intestinal microflora</topic><topic>Lacticaseibacillus rhamnosus - physiology</topic><topic>Lactobacillus rhamnosus</topic><topic>Long-term effects</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>multidisciplinary</topic><topic>Pecking behavior</topic><topic>Probiotics</topic><topic>Quantitative Trait, Heritable</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Serotonin</topic><topic>Stress, Physiological - immunology</topic><topic>Tryptophan</topic><topic>Tryptophan - blood</topic><topic>Tryptophan - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mindus, Claire</creatorcontrib><creatorcontrib>van Staaveren, Nienke</creatorcontrib><creatorcontrib>Fuchs, Dietmar</creatorcontrib><creatorcontrib>Gostner, Johanna M.</creatorcontrib><creatorcontrib>Kjaer, Joergen B.</creatorcontrib><creatorcontrib>Kunze, Wolfgang</creatorcontrib><creatorcontrib>Mian, M. Firoz</creatorcontrib><creatorcontrib>Shoveller, Anna K.</creatorcontrib><creatorcontrib>Forsythe, Paul</creatorcontrib><creatorcontrib>Harlander-Matauschek, Alexandra</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mindus, Claire</au><au>van Staaveren, Nienke</au><au>Fuchs, Dietmar</au><au>Gostner, Johanna M.</au><au>Kjaer, Joergen B.</au><au>Kunze, Wolfgang</au><au>Mian, M. Firoz</au><au>Shoveller, Anna K.</au><au>Forsythe, Paul</au><au>Harlander-Matauschek, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>L. rhamnosus improves the immune response and tryptophan catabolism in laying hen pullets</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>19538</spage><epage>19538</epage><pages>19538-19538</pages><artnum>19538</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>In mammals, early-life probiotic supplementation is a promising tool for preventing unfavourable, gut microbiome-related behavioural, immunological, and aromatic amino acid alterations later in life. In laying hens, feather-pecking behaviour is proposed to be a consequence of gut-brain axis dysregulation.
Lactobacillus rhamnosus
decreases stress-induced severe feather pecking in adult hens, but whether its effect in pullets is more robust is unknown. Consequently, we investigated whether early-life, oral supplementation with a single
Lactobacillus rhamnosus
strain can prevent stress-induced feather-pecking behaviour in chickens. To this end, we monitored both the short- and long-term effects of the probiotic supplement on behaviour and related physiological parameters. We hypothesized that
L. rhamnosus
would reduce pecking behaviour by modulating the biological pathways associated with this detrimental behaviour, namely aromatic amino acid turnover linked to neurotransmitter production and stress-related immune responses. We report that stress decreased the proportion of cytotoxic T cells in the tonsils (P = 0.047). Counteracting this T cell depression, birds receiving the
L. rhamnosus
supplementation significantly increased all T lymphocyte subset proportions (P < 0.05). Both phenotypic and genotypic feather peckers had lower plasma tryptophan concentrations compared to their non-pecking counterparts. The probiotic supplement caused a short-term increase in plasma tryptophan (P < 0.001) and the TRP:(PHE + TYR) ratio (P < 0.001). The administration of stressors did not significantly increase feather pecking in pullets, an observation consistent with the age-dependent onset of pecking behaviour. Despite minimal changes to behaviour, our data demonstrate the impact of
L. rhamnosus
supplementation on the immune system and the turnover of the serotonin precursor tryptophan. Our findings indicate that
L. rhamnosus
exerts a transient, beneficial effect on the immune response and tryptophan catabolism in pullets.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34599202</pmid><doi>10.1038/s41598-021-98459-x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Scientific reports, 2021-10, Vol.11 (1), p.19538-19538, Article 19538 |
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| source | Publicly Available Content (ProQuest); PubMed Central; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/601/1737 631/601/18 Age Age Factors Amino acids Animals Behavior, Animal Biomarkers Birds Chickens Cytotoxicity Dietary supplements Feathers Genetic Association Studies Genetic Background Host Microbial Interactions Humanities and Social Sciences Immune response Immune system Immunity Intestinal microflora Lacticaseibacillus rhamnosus - physiology Lactobacillus rhamnosus Long-term effects Lymphocytes Lymphocytes T Microbiomes Microbiota multidisciplinary Pecking behavior Probiotics Quantitative Trait, Heritable Science Science (multidisciplinary) Serotonin Stress, Physiological - immunology Tryptophan Tryptophan - blood Tryptophan - metabolism |
| title | L. rhamnosus improves the immune response and tryptophan catabolism in laying hen pullets |
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