The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress

Age-associated changes in chromatin structure have a major impact on organismal longevity. Despite being a central part of the ageing process, the organismal responses to the changes in chromatin organization remain unclear. Here we show that moderate disturbance of histone balance during C . elegan...

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Bibliographic Details
Published in:Nature communications 2017-11, Vol.8 (1), p.1818-11, Article 1818
Main Authors: Matilainen, Olli, Sleiman, Maroun S. Bou, Quiros, Pedro M., Garcia, Susana M. D. A., Auwerx, Johan
Format: Article
Language:English
Subjects:
631/337/470/1981
631/443/7
Chromatin
Chromatin remodeling
Developmental stages
Heat shock proteins
Humanities and Social Sciences
Longevity
Mitochondria
multidisciplinary
Proteins
Science
Science (multidisciplinary)
Stress
Stress response
Stresses
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Summary:Age-associated changes in chromatin structure have a major impact on organismal longevity. Despite being a central part of the ageing process, the organismal responses to the changes in chromatin organization remain unclear. Here we show that moderate disturbance of histone balance during C . elegans development alters histone levels and triggers a stress response associated with increased expression of cytosolic small heat-shock proteins. This stress response is dependent on the transcription factor, HSF-1, and the chromatin remodeling factor, ISW-1. In addition, we show that mitochondrial stress during developmental stages also modulates histone levels, thereby activating a cytosolic stress response similar to that caused by changes in histone balance. These data indicate that histone and mitochondrial perturbations are both monitored through chromatin remodeling and involve the activation of a cytosolic response that affects organismal longevity. HSF-1 and ISW-1 hence emerge as a central mediator of this multi-compartment proteostatic response regulating longevity. Changes in chromatin structure have been linked to organismal ageing. Here the authors show that altered histone expression and mitochondrial stress during C. elegans development result in chromatin changes and a cytosolic stress response that affects organismal longevity, and depends on HSF-1 and the chromatin remodeller, ISW-1.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-017-01903-8