Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure-Activity Relationship and Mechanism of Action

Curcumin, one of the major ingredients of turmeric ( ), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin's low bioavailability limits its potential as an antimalarial and anti-inflammatory agent. Therefore, re...

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Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2023-04, Vol.16 (4), p.609
Main Authors: Jamil, Siti Nur Hidayah, Ali, Amatul Hamizah, Feroz, Shevin Rizal, Lam, Su Datt, Agustar, Hani Kartini, Mohd Abd Razak, Mohd Ridzuan, Latip, Jalifah
Format: Article
Language:English
Subjects:
anti-inflammatory
Anti-inflammatory agents
Anti-inflammatory drugs
antimalaria
Antimalarials
Bioavailability
Biological activity
Chemical properties
curcumin derivatives
Drug resistance
Drugs
Evaluation
Health aspects
Infections
Malaria
Metabolism
molecular targets
Parasites
Pharmacokinetics
Review
Structure-activity relationship (Pharmacology)
Structure-activity relationships
structure–activity relationship
Testing
Turmeric
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Summary:Curcumin, one of the major ingredients of turmeric ( ), has been widely reported for its diverse bioactivities, including against malaria and inflammatory-related diseases. However, curcumin's low bioavailability limits its potential as an antimalarial and anti-inflammatory agent. Therefore, research on the design and synthesis of novel curcumin derivatives is being actively pursued to improve the pharmacokinetic profile and efficacy of curcumin. This review discusses the antimalarial and anti-inflammatory activities and the structure-activity relationship (SAR), as well as the mechanisms of action of curcumin and its derivatives in malarial treatment. This review provides information on the identification of the methoxy phenyl group responsible for the antimalarial activity and the potential sites and functional groups of curcumin for structural modification to improve its antimalarial and anti-inflammatory actions, as well as potential molecular targets of curcumin derivatives in the context of malaria and inflammation.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph16040609