Serologic response and safety of COVID-19 vaccination in HSCT or CAR T-cell recipients: a systematic review and meta-analysis

• Published in: Experimental hematology & oncology 2022-08, Vol.11 (1), p.1-46, Article 46
• Main Authors: Ge, Chenghao, Du, Kelei, Luo, Mingjie, Shen, Kaini, Zhou, Yangzhong, Guo, Kaiyuan, Liu, Yang, Yin, Chen, Li, Yi, Li, Guanqiao, Chen, Xiaoyuan
• Format: Article
• Language: English
• Subjects: Antigens; Bias; Blood diseases; Chimeric antigen receptor T cell therapy; Clinical trials; Coronaviruses; COVID-19; COVID-19 vaccines; Health aspects; Hematopoietic stem cell transplantation; Hematopoietic stem cells; Immune system; Immunology; Infection; Medical research; Medicine, Experimental; Meta-analysis; Multiple myeloma; Pandemics; Safety and security measures; Severe acute respiratory syndrome coronavirus 2; Stem cell transplantation; T cells; Transplantation; Transplants & implants; Vaccination; Vaccine
• ISSN: 2162-3619; 2162-3619
• DOI: 10.1186/s40164-022-00299-6

Background Patients receiving hematopoietic stem cell transplantation (HSCT) or chimeric antigen receptor T cell (CAR T-cell) therapy are immunocompromised and at high risk of viral infection, including SAR2-CoV-2 infection. However, the effectiveness and safety of COVID-19 vaccines in these recipients is not well characterized. The present meta-analysis evaluated the serologic response and safety of COVID-19 vaccines in these population. Methods Literature databases (MEDLINE, EMBASE, Web of Science, MedRvix and BioRvix) were searched for original studies with serologic response post COVID-19 vaccination in HSCT or CAR T-cell recipients published until July 14, 2022. The analysis included 27 observational studies with a total of 2899 patients receiving allogeneic HSCT (2506), autologous HSCT (286) or CAR T-cell therapy (107), and 683 healthy participants with serologic response data. Random effects models were used to pool the rate of serologic response to COVID-19 vaccination in HSCT or CAR T-cell recipients and odds ratio comparing with healthy controls. Results The pooled seropositivity rates in HSCT and CAR T-cell recipients were 0.624 [0.506-0.729] for one dose, 0.745 [0.712-0.776] for two doses. The rates were significantly lower than those in healthy controls (nearly 100%). In subgroup analysis, CAR T-cell recipients exhibited an even lower seroconversion rate (one dose: 0.204 [0.094-0.386]; two doses: 0.277 [0.190-0.386]) than HSCT counterparts (one dose: 0.779 [0.666-0.862]; two doses: 0.793 [0.762-0.821]). The rates were comparable between autologous and allogeneic HSCT recipients. Other possible impact factors related to seropositivity were time interval between therapy and vaccination, use of immunosuppressive drugs and immune cell counts. Most vaccine-related adverse effects were mild and resolvable, comparable to general population. Conclusions This analysis revealed a diminished response to COVID-19 vaccines in HSCT or CAR T-cell recipients. Our findings may inform regular COVID-19 vaccination at appropriate intervals after HSCT or CAR T-cell therapy. Keywords: COVID-19, Vaccine, Hematopoietic stem cell transplantation, Chimeric antigen receptor T cell therapy, Meta-analysis