Cardiovascular risk assessment in type 2 diabetes mellitus: comparison of the World Health Organization/International Society of Hypertension risk prediction charts versus UK Prospective Diabetes Study risk engine

• Published in: Vascular health and risk management 2015-01, Vol.11 (default), p.583-589
• Main Authors: Herath, Herath M Meththananda, Weerarathna, Thilak Priyantha, Umesha, Dilini
• Format: Article
• Language: English
• Subjects: Adult; Age; Biomarkers - blood; Blood Pressure; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Cholesterol; Cholesterol, LDL - blood; Comorbidity; Comparative analysis; Coronary vessels; Cross-Sectional Studies; Decision Support Techniques; Diabetes; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - epidemiology; Disease prevention; Dyslipidemias - diagnosis; Dyslipidemias - epidemiology; Female; Health risk assessment; Heart; Humans; Hypertension; Hypertension - diagnosis; Hypertension - epidemiology; Lipids; Low density lipoprotein; Male; Middle Aged; Minority & ethnic groups; Original Research; Physiological aspects; Practice guidelines (Medicine); Predictive Value of Tests; Prevalence; Primary care; Reproducibility of Results; Risk Assessment; Risk Factors; Smoking; Sri Lanka - epidemiology; Type 2 diabetes; Up-Regulation; Validity
• ISSN: 1178-2048; 1176-6344; 1178-2048
• DOI: 10.2147/VHRM.S90126

Patients with type 2 diabetes mellitus (T2DM) are at higher risk of developing cardiovascular diseases, and assessment of their cardiac risk is important for preventive strategies. The Ministry of Health of Sri Lanka has recommended World Health Organization/International Society of Hypertension (WHO/ISH) charts for cardiac risk assessment in individuals with T2DM. However, the most suitable cardiac risk assessment tool for Sri Lankans with T2DM has not been studied. This study was designed to evaluate the performance of two cardiac risk assessments tools; WHO/ISH charts and UK Prospective Diabetes Study (UKPDS) risk engine. Cardiac risk assessments were done in 2,432 patients with T2DM attending a diabetes clinic in Southern Sri Lanka using the two risk assessment tools. Validity of two assessment tools was further assessed by their ability to recognize individuals with raised low-density lipoprotein (LDL) and raised diastolic blood pressure in a cohort of newly diagnosed T2DM patients (n=332). WHO/ISH charts identified 78.4% of subjects as low cardiac risk whereas the UKPDS risk engine categorized 52.3% as low cardiac risk (P