A Computer Simulation Research of Two Types of Cardiac Physiological Pacing

This manuscript adopted the cardiac modeling and simulation method to study the problems of physiological pacing in clinical application. A multiscale rabbit ventricular electrophysiological model was constructed. We simulated His-bundle pacing (HBP) treatment for left bundle branch block (LBBB) and...

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Bibliographic Details
Published in:Applied sciences 2021-01, Vol.11 (1), p.449
Main Authors: Zhu, Honglei, Jin, Lian, Huang, Yanqi, Wu, Xiaomei
Format: Article
Language:English
Subjects:
atrioventricular block
cardiac modeling
Clinical medicine
Computer simulation
EKG
Electrocardiography
Excitation
Heart
is-bundle pacing
left bundle branch block
left bundle branch pacing
Morphology
Physiology
Simulation
Ventricle
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Summary:This manuscript adopted the cardiac modeling and simulation method to study the problems of physiological pacing in clinical application. A multiscale rabbit ventricular electrophysiological model was constructed. We simulated His-bundle pacing (HBP) treatment for left bundle branch block (LBBB) and atrioventricular block (AVB), and left bundle branch pacing (LBBP) treatment for LBBB by setting various moments of the stimulus. The synthetic ECGs and detailed electrical activities were analyzed. Our electrophysiological model accurately simulated the normal state, HBP, and LBBP. The synthetic ECG showed that QRS duration was narrowed by 30% after HBP correction for LBBB. For LBBB correction with LBBP, the synthetic ECGs of LBBP starting before 30 ms (if the end of atrial excitation is set as 0 ms) presented right bundle branch block (RBBB), and those of LBBP starting at 30–38 ms were synchronous, while those of LBBP starting after 42 ms possessed LBBB morphologies. The best pacing results were obtained when LBBP started at 34 ms. This manuscript verified the feasibility of the constructed ventricular model, and studied the physiological pacing mechanism. The results showed that HBP realized correction for AVB and high LBBB. The performance of LBBP can be improved by applying the stimulus within a specific period of time (0–8 ms) after atrial excitation.
ISSN:2076-3417
2076-3417
DOI:10.3390/app11010449