Machine Learning-Based Prediction of Pulmonary Embolism Prognosis Using Nutritional and Inflammatory Indices

• Published in: Clinical and applied thrombosis/hemostasis 2024-01, Vol.30, p.10760296241300484
• Main Authors: Lian, Zengzhi, Wei, Xue-ni, Chai, Dayang
• Format: Article
• Language: English
• Subjects: Aged; Blood pressure; Female; Humans; Inflammation - blood; Machine Learning; Male; Middle Aged; Original; Prognosis; Pulmonary Embolism - blood; Pulmonary Embolism - diagnosis; Respiratory failure; Retrospective Studies
• ISSN: 1076-0296; 1938-2723; 1938-2723
• DOI: 10.1177/10760296241300484

Purpose This study aimed to create and assess machine learning (ML) models that utilize nutritional and inflammatory indices, focusing on the advanced lung cancer inflammation index (ALI) and neutrophil-to-albumin ratio (NAR), to improve the prediction accuracy of PE prognosis. Patients and methods We conducted a retrospective analysis of 312 patients, comprising 254 survivors and 58 non-survivors. The Boruta algorithm was used to identify significant variables, and four ML models (XGBoost, Random Forest, Logistic Regression, and SVM) were employed to analyze the clinical data and assess the performance of the models. Results The XGBoost model, with optimal hyperparameters, achieved the best performance, with an accuracy of 0.882, an F1-score of 0.889, a precision of 0.917, a sensitivity of 0.863, a specificity of 0.905, and an AUC of 0.873. Analysis of feature importance indicated that the most critical predictors across models were respiratory failure, log-transformed ALI, albumin level, age, diastolic blood pressure, and NAR. Conclusion The ML-based prediction models effectively predicted the prognosis of PE, with the XGBoost model exhibiting good performance. Respiratory failure, ALI, albumin level, age, diastolic blood pressure, and NAR were correlated with PE prognosis.