The combined effects of cholesteryl ester transfer protein ( CETP ) TaqIB gene polymorphism and canola, sesame and sesame-canola oils consumption on metabolic response in patients with diabetes and healthy people

• Published in: Journal of cardiovascular and thoracic research 2020-01, Vol.12 (3), p.185-194
• Main Authors: Ramezani-Jolfaie, Nahid, Aghaei, Shiva, Farashahi Yazd, Ehsan, Moradi, Ali, Mozaffari-Khosravi, Hassan, Amiri, Mojgan, Raeisi-Dehkordi, Hamidreza, Moghtaderi, Fatemeh, Zimorovat, Alireza, Yasini Ardakani, Seyed Ali, Salehi-Abargouei, Amin
• Format: Article
• Language: English
• Subjects: Blood pressure; Canola; canola oil; Cardiovascular disease; Cholesterol; cholesterol ester transfer proteins; Coronary vessels; Diabetes; diabetes mellitus; Fatty acids; Genotype & phenotype; Glucose; Insulin resistance; Intervention; Investigations; Lipids; Lipoproteins; Metabolism; Oils & fats; Original; Polymorphism; Proteins; sesame oil; sesame-canola oil; Vegetable oils
• ISSN: 2008-5117; 2008-6830
• DOI: 10.34172/jcvtr.2020.32

Keywords: Cholesterol Ester Transfer Proteins Diabetes Mellitus Sesame Oil Canola Oil Sesame-Canola Oil Polymorphism Abstract Introduction: Cholesteryl ester transfer protein (CETP) is a key regulating enzyme in the lipid metabolism pathway, and its gene polymorphism may be a candidate for modulating the metabolic responses to dietary intervention. A large body of evidence has suggested that a reduction of saturated fatty acids (SFAs) and its substitution with unsaturated fatty acids (UFAs) might help to improve insulin sensitivity and circulating lipid levels, as well as cardiovascular risk.1-4 Some of plant-based oils that contain considerable amounts of mono- (MUFAs) and polyunsaturated fatty acids (PUFAs) are being investigated as suitable alternatives for dietary oils rich in saturated and trans-fatty acids.5 Healthy vegetable oils such as canola and sesame oils with high contents of MUFAs (e.g. oleic acid), PUFAs (e.g. alpha-linolenic acid and linoleic acid), and antioxidants (e.g. tocopherol, lignans, and phytosterols) have been reported to be beneficial in improving cardiovascular risk factors, although some other studies were controversial.6-10 These inconsistent observations have been proposed to be related to the combined effects of genetic and environmental factors (e.g. dietary intake) that justified different individual responses to dietary interventions in general.11 Genetic variations including single-nucleotide polymorphisms (SNPs) in the genes that encode proteins involved in lipid and glycemic metabolism, may play a major role in changes in metabolic profile.12 The human cholesteryl ester transfer protein (CETP) gene is localized on chromosome 16 in the region of q21 (16q21) and contained 16 exons and 15 introns.13 This gene encodes a protein containing 476 amino acids as one of the key enzymes in lipid metabolism that plays an important role in reverse-cholesterol transport resulting in decreasing high-density lipoprotein (HDL) cholesterol and increasing the cholesterol content of low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol. [...]it transfers cholesterol ester from HDL to apo B-containing lipoproteins such as LDL, VLDL and VLDL remnants in exchange for triglyceride and subsequent uptake of cholesterol by hepatocytes.14 TaqIB is a common polymorphism in the CETP gene, which is located in nucleotide 277 of intron 1 and characterized by a silent base change from G [called as B1 allele (presence of the