High Number and Specific Comorbidities Could Impact the Immune Response in COVID-19 Patients

• Published in: Frontiers in immunology 2022-07, Vol.13, p.899930-899930
• Main Authors: Liu, Dafeng, Yuan, Xiaoyan, Gao, Fengjiao, Zhao, Bennan, Ding, Ling, Huan, Mingchang, Liu, Chao, Jiang, Liangshuang
• Format: Article
• Language: English
• Subjects: comorbidities; coronavirus disease 2019 (COVID-19); immune response; Immunology; impact; lymphocyte subsets
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2022.899930

BackgroundCellular immunodeficiency and comorbidities are common in COVID-19 patients.AimThe purpose of this study was to investigate comorbidities impacting on the cellular immunity in COVID-19 patients.MethodsThe research objects included 55 healthy controls and 718 COVID-19 patients who divided into the control group and the COVID-19 group, respectively. Those in the COVID-19 group were divided into subgroups on the basis of the number and types of comorbidities present. Lymphocyte itself and its subsets were compared between the control group and the COVID-19 group, the groups with comorbidities based on the different number and types of comorbidities, and the relationship between the lymphocyte counts and subsets with the number and types of comorbidities was investigated.ResultsCompared with the control group, the lymphocyte counts and T cell subsets were significantly increased in the groups with comorbidities, but both B and NK cell subsets were significantly decreased in the no comorbidity group and in most of the groups with comorbidities (all P