Schiff bases and their metal complexes as urease inhibitors – A brief review

[Display omitted] Schiff bases, an aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine, are some of the most widely used organic compounds. Indeed, they are widely used for industrial purposes and also exhibit a broad range of biological activities, i...

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Bibliographic Details
Published in:Journal of advanced research 2018-09, Vol.13, p.113-126
Main Authors: de Fátima, Ângelo, Pereira, Camila de Paula, Olímpio, Carolina Raquel Said Dau Gonçalves, de Freitas Oliveira, Breno Germano, Franco, Lucas Lopardi, da Silva, Pedro Henrique Corrêa
Format: Article
Language:English
Subjects:
Canavalia ensiformis
Helicobacter pylori
Metal complex
Schiff base
Urea
Urease
Urease inhibitor
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Summary:[Display omitted] Schiff bases, an aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine, are some of the most widely used organic compounds. Indeed, they are widely used for industrial purposes and also exhibit a broad range of biological activities, including anti-urease activity. Ureases, enzymes that catalyze urea hydrolysis, have received considerable attention for their impact on living organisms’ health, since the persistence of urease activity in human and animal cells can be the cause of some diseases and pathogen infections. This short review compiles examples of the most antiurease Schiff bases (0.23 μM 
ISSN:2090-1232
2090-1224
DOI:10.1016/j.jare.2018.03.007