Impact of diabetes on coronary physiology evaluated by quantitative flow ratio in patients who underwent percutaneous coronary intervention

• Published in: Journal of diabetes investigation 2022-07, Vol.13 (7), p.1203-1212
• Main Authors: Ye, Zhen, Chen, Qin, Zhong, Jiaxin, Chen, Long, Chen, Lihua, Ye, Mingfang, Yan, Yuanming, Chen, Lianglong, Luo, Yukun
• Format: Article
• Language: English
• Subjects: Angina pectoris; Angioplasty; Cardiovascular disease; Clinical outcomes; Coronary vessels; Creatinine; Diabetes; Diabetes mellitus; Ejection fraction; Flow velocity; Glucose; Heart attacks; Hospitalization; Hypertension; Medical imaging; Medical records; Original; Patients; Peptides; Percutaneous coronary intervention; Physiology; Quantitative flow ratio; Restenosis; Vein & artery diseases
• ISSN: 2040-1116; 2040-1124
• DOI: 10.1111/jdi.13779

ABSTRACT Aims/Introduction There are mixed opinions on the influence of diabetes on the prognosis of patients receiving percutaneous coronary intervention (PCI). Therefore, in this study, the quantitative flow ratio (QFR), an emerging technology of functional evaluation, was used to explore the impact of diabetes on coronary physiology in patients who underwent PCI. Materials and Methods Patients who underwent successful PCI and a 1‐year angiographic follow up were retrospectively screened and analyzed by the QFR. Based on the presence or absence of diabetes, 677 enrolled patients (794 vessels) were classified into a diabetes group (211 patients, 261 vessels) and a non‐diabetes group (466 patients, 533 vessels). The results of QFR analysis and clinical outcomes were compared between the two groups. Results The two groups reached a similar level of post‐PCI QFR (0.95 ± 0.09 vs 0.96 ± 0.06, P = 0.292). However, at the 1‐year follow up, the QFR was lower (0.93 ± 0.11 vs 0.96 ± 0.07, P