Abnormal anal cytology risk in women with known genital squamous intraepithelial lesion

• Published in: The Brazilian journal of infectious diseases 2016-05, Vol.20 (3), p.294-297
• Main Authors: do Socorro Nobre, Maria, Jacyntho, Claudia Marcia, Eleutério, José, Giraldo, Paulo César, Gonçalves, Ana Katherine
• Format: Article
• Language: English
• Subjects: Adult; Anal Canal - pathology; Anal Canal - virology; Anal cancer; Brief Communication; Cancer; Case-Control Studies; Complications and side effects; Cytodiagnosis; Female; Genital diseases, Female; Humans; INFECTIOUS DISEASES; Methods; Papanicolaou Test; Papillomaviridae - isolation & purification; Papillomavirus; Papillomavirus Infections - pathology; Papillomavirus Infections - virology; Risk Factors; Sexual Behavior; Squamous cell carcinoma; Squamous Intraepithelial Lesions of the Cervix - pathology; Squamous Intraepithelial Lesions of the Cervix - virology; Uterine Cervical Neoplasms - pathology
• ISSN: 1413-8670; 1678-4391; 1678-4391
• DOI: 10.1016/j.bjid.2016.01.008

The purpose of this study was to assess the risk of abnormal anal cytology in women with known genital squamous intraepithelial lesion. This study evaluated 200 women with and without genital squamous intraepithelial lesion who were recruited for anal Pap smears. Women who had abnormal results on equally or over atypical squamous cells of undetermined significance were classified as having abnormal anal cytology. A multiple logistic regression analysis (stepwise) was performed to identify the risk for developing abnormal anal cytology. Data were analyzed using the SPSS 20.0 program. The average age was 41.09 (±12.64). Of the total participants, 75.5% did not practice anal sex, 91% did not have HPV-infected partners, 92% did not have any anal pathology, and 68.5% did not have anal bleeding. More than half (57.5%) had genital SIL and a significant number developed abnormal anal cytology: 13% in the total sample and 17.4% in women with genital SIL. A significant association was observed between genital squamous intraepithelial lesion and anal squamous intraepithelial lesion (PR=2.46; p=0.03). In the logistic regression model, women having genital intraepithelial lesion were more likely to have abnormal anal Pap smear (aPR=2.81; p=0.02). This report shows that women with genital squamous intraepithelial lesion must be more closely screened for anal cancer.