Characterization of cardiac fibroblast-extracellular matrix crosstalk across developmental ages provides insight into age-related changes in cardiac repair

Heart failure afflicts an estimated 6.5 million people in the United States, driven largely by incidents of coronary heart disease (CHD). CHD leads to heart failure due to the inability of adult myocardial tissue to regenerate after myocardial infarction (MI). Instead, immune cells and resident card...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2024, Vol.12, p.1279932-1279932
Main Authors: Perreault, Luke R, Daley, Mark C, Watson, Matthew C, Rastogi, Sagar, Jaiganesh, Ajith, Porter, Elizabeth C, Duffy, Breanna M, Black, 3rd, Lauren D
Format: Article
Language:English
Subjects:
cardiac development
cardiac fibroblast
extracellular matrix
fibrosis
wound healing
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Summary:Heart failure afflicts an estimated 6.5 million people in the United States, driven largely by incidents of coronary heart disease (CHD). CHD leads to heart failure due to the inability of adult myocardial tissue to regenerate after myocardial infarction (MI). Instead, immune cells and resident cardiac fibroblasts (CFs), the cells responsible for the maintenance of the cardiac extracellular matrix (cECM), drive an inflammatory wound healing response, which leads to fibrotic scar tissue. However, fibrosis is reduced in fetal and early (
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2024.1279932