Hippocampal neurogenesis and pro‐neurogenic therapies for Alzheimer's disease

Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elde...

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Bibliographic Details
Published in:Animal models and experimental medicine 2022-02, Vol.5 (1), p.3-14
Main Author: Zheng, Jie
Format: Article
Language:English
Subjects:
Age
Aged
Aging
Alzheimer Disease
Alzheimer's disease
Animal models
Animals
Biomarkers
Brain
Cell growth
Cognition
Cognition - physiology
cognitive deficit
Dementia
Dementia disorders
Hippocampal plasticity
Hippocampus
Humans
Neurodegeneration
Neurodegenerative diseases
Neurogenesis
Neurogenesis - physiology
Neuronal-glial interactions
Neurons
Proteins
pro‐neurogenic therapy
Review
Themed Section: Neurodegenerative Disease
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Summary:Adult hippocampal neurogenesis (AHN) facilitates hippocampal circuits plasticity and regulates hippocampus‐dependent cognition and emotion. However, AHN malfunction has been widely reported in both human and animal models of Alzheimer's disease (AD), the most common form of dementia in the elderly. Pro‐neurogenic therapies including rescuing innate AHN, cell engraftment and glia‐neuron reprogramming hold great potential for compensating the neuronal loss and rewiring the degenerated neuronal network in AD, but there are still great challenges to be overcome. This review covers recent advances in unraveling the involvement of AHN in AD and highlights the prospect of emerging pro‐neurogenic remedies. Innate AHN can be facilitated by pro‐neurogenic drugs, environmental enrichment combined with exercise, neurostimulation and dietary innervation. More extensive neurogenesis can be also induced by transplantation of stem cells or neural progenitors, as well as genetic induction of glia‐neuron conversion.
ISSN:2576-2095
2096-5451
2576-2095
DOI:10.1002/ame2.12212