Association between infectious burden and cerebral microbleeds: a pilot cross‐sectional study

Objective Cerebral microbleeds (CMBs) is a subtype of cerebral small vessel disease. Their underlying pathogenesis remains unclear. The aim of this study was to investigate the association between infectious burden (IB) and CMBs. Methods Seven hundred and seventy‐three consecutive patients who were...

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Published in:Annals of clinical and translational neurology 2021-02, Vol.8 (2), p.395-405
Main Authors: Fan, Fan, Yang, Cui, Zhu, Xiaoyan, Liu, Zhilan, Liu, Hui, Li, Jianhao, Jiang, Rui, Zhang, Yaolei, Bu, Xianle, Wang, Yanjiang, Wang, Qingsong, Xiang, Yang
Format: Article
Language:English
Subjects:
Age
Atherosclerosis
Blood pressure
Cardiovascular disease
Cholesterol
Cross-sectional studies
Cytomegalovirus
Diabetes
Fasting
Glucose
Hypertension
Infections
Laboratories
Magnetic resonance imaging
Pathogenesis
Pathogens
Regression analysis
Statistical analysis
Stroke
Triglycerides
Tumor necrosis factor-TNF
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Summary:Objective Cerebral microbleeds (CMBs) is a subtype of cerebral small vessel disease. Their underlying pathogenesis remains unclear. The aim of this study was to investigate the association between infectious burden (IB) and CMBs. Methods Seven hundred and seventy‐three consecutive patients who were hospitalized in the Department of Neurology in General Hospital of Western Theater Command without severe neurological symptoms were recruited and selected in this pilot cross‐sectional study. CMBs were assessed using the susceptibility‐weighted imaging sequence of magnetic resonance imaging. Immunoglobulin G antibodies against common pathogens, including herpes simplex virus (HSV)‐1, HSV‐2, cytomegalovirus (CMV), Chlamydia pneumoniae (C. pneumoniae), Mycoplasma pneumoniae (M. pneumoniae), Epstein‐Barr virus (EBV), Helicobacter pylori (HP), and Borrelia burgdorferi (B. burgdorferi), were measured by commercial ELISA assays. IB was defined as a composite serologic measure of exposure to these common pathogens. Results Patients with and without CMBs were defined as the CMBs group (n = 76) and the non‐CMBs group (n = 81), respectively. IB was significantly different between the CMBs and non‐CMBs groups. After adjusted for other risk factors, the increased IB was independently associated with the presence of CMBs (P = 0.031, OR = 3.00, 95% CI [1.11–8.15]). IB was significantly positively associated with the number of CMBs (Spearman ρ = 0.653, P 
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.51285