Factors leading to refractory asthma in patients from Saudi Arabia

• Published in: Annals of thoracic medicine 2017-01, Vol.12 (1), p.42-45
• Main Authors: Al-Moamary, Amal, Al-Hajjaj, Mohamed, Al Moamary, Mohamed
• Format: Article
• Language: English
• Subjects: Allergies; Asthma; Care and treatment; Chronic obstructive pulmonary disease; Comorbidity; Demographics; difficult-to-treat asthma; Dosage and administration; Gastroesophageal reflux; Health risk assessment; Heart failure; Original; Patients; refractory asthma; Saudi Arabia; Steroids (Drugs); Studies
• ISSN: 1817-1737; 1998-3557
• DOI: 10.4103/1817-1737.197776

AIM: The aim of this study was to study the clinical characteristic of patient with refractory asthma (RA) from Saudi Arabia. METHODS: This paper prospectively studied in a university hospital factors leading to RA in a cohort of patients who have inadequately controlled asthma or with frequent exacerbations despite optimum controller therapy. It also studied patients with asthma that requires extended periods of oral steroids to control. RESULTS: The mean age was 45.1 years (±9.1) where 74 patients were enrolled in this study with the age group (37-48 years) is having the highest percentage (64.8%). Female patients represented 62.2%. The two major comorbid conditions were allergic rhinitis (54.1%) and gastroesophageal reflux (33.8%). The vast majority (72 patients) had at least one trigger factor for asthma (97.3%). The asthma control test showed that 86.4% had an uncontrolled status. Spirometry showed mild disease in 9.5%, moderate in 47.3%, and severe in 43.2%. Eosinophilia was seen in only 16.2%. Immunoglobulin E level between 70 and 700 μg/L was found in 58.1% of patients. CONCLUSION: RA has certain clinical characteristics and associated comorbid conditions as well as precipitating factors that facilitate the identifications of these cases.