Sida acuta Burm.f. leaves ethanol extract ameliorates haematological and biochemical alterations induced by Plasmodium berghei ANKA-65 in mice

Background Malaria has continued to be a threat to man and his wellbeing, especially Africans and Asians. New antimalarial drugs are urgently needed to mitigate malaria treatment failure due to resistant Plasmodium species . Medicinal plants used by indigenous Nigerians for treating fever and malari...

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Bibliographic Details
Published in:Clinical phytoscience 2021-10, Vol.7 (1), p.1-12, Article 78
Main Authors: Enechi, Osmond Chukwuma, Amah, Christian Chijioke, Okagu, Innocent Uzochukwu, Ononiwu, Pamela Chidinma, Nweke, Alice Chinwendu, Ugwuanyi, Theophilus Chukwudi, Ajibo, Emmanuel Arinzechukwu, Nweze, Anthonia Chiamaka, Chukwurah, Blessing Chiamaka
Format: Article
Language:English
Subjects:
Acute toxicity
Antimalarial activity
Antimalarial agents
Antioxidants
Artemether
Biochemical parameters
Biochemistry
Blood levels
Cell size
Diabetes
Drug abuse
Drugs
Erythrocytes
Ethanol
Fever
Gastroenterology
Gynecology
Haematological indices
Hematology
Hemoglobin
Herbal medicine
Indicators
Indigenous plants
Lead compounds
Leaves
Leukocytes
Lipid peroxidation
Lipids
Malaria
Medicinal plants
Medicine
Medicine & Public Health
Original Contribution
Parasitemia
Parasites
Pediatrics
Peroxidation
Plasmodium berghei
Pneumology/Respiratory System
Sida acuta
Sida acuta Burm.f
Toxicity
Vector-borne diseases
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Summary:Background Malaria has continued to be a threat to man and his wellbeing, especially Africans and Asians. New antimalarial drugs are urgently needed to mitigate malaria treatment failure due to resistant Plasmodium species . Medicinal plants used by indigenous Nigerians for treating fever and malaria such as Sida acuta Burm.f. (Malvaceae) could be a promising source of lead compounds for developing new generations of antimalarial drugs. The effects of ethanol extract of S. acuta leaves (EESAL) on malaria parasitemia, haematological and biochemical status of P. berghei -infected mice were investigated, using the 4-day curative test. Methodology EESAL was prepared by maceration method. The phyto-constituents and acute toxicity profile of the extract were evaluated using standard protocols. In addition, malaria parasitemia and chemo-suppression, and indicators of haematological and biochemical status of P. berghei -infected mice treated with EESAL were assessed. Results At 200, 400 and 600 mg/kg/d b.w., p.o doses for 4 consecutive days, EESAL significantly ( p  
ISSN:2199-1197
2199-1197
DOI:10.1186/s40816-021-00317-w