The Gut Microbiome Profile in Obesity: A Systematic Review

Gut microbiome has been identified in the past decade as an important factor involved in obesity, but the magnitude of its contribution to obesity and its related comorbidities is still uncertain. Among the vast quantity of factors attributed to obesity, environmental, dietary, lifestyle, genetic, a...

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Bibliographic Details
Published in:International journal of endocrinology 2018-01, Vol.2018 (2018), p.1-9
Main Authors: Schröder, Helmut, Magkos, Faidon, Lee, Seung-Hwan, Park, Yong-Moon, Goday, Albert, Castañer, Olga, Shiow, Sue-Anne Toh Ee
Format: Article
Language:English
Subjects:
Analysis
Body mass index
Clinical trials
Collaboration
Deoxyribonucleic acid
Diabetes
Digestive system
Disease
DNA
Endocrinology
Feces
Gastrointestinal surgery
Metabolism
Microbiota
Microbiota (Symbiotic organisms)
Mortality
Obesitat
Obesity
Review
Studies
Surgery
Type 2 diabetes
Weight control
Womens health
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Summary:Gut microbiome has been identified in the past decade as an important factor involved in obesity, but the magnitude of its contribution to obesity and its related comorbidities is still uncertain. Among the vast quantity of factors attributed to obesity, environmental, dietary, lifestyle, genetic, and others, the microbiome has aroused curiosity, and the scientific community has published many original articles. Most of the studies related to microbiome and obesity have been reported based on the associations between microbiota and obesity, and the in-depth study of the mechanisms related has been studied mainly in rodents and exceptionally in humans. Due to the quantity and diverse information published, the need of reviews is mandatory to recapitulate the relevant achievements. In this systematic review, we provide an overview of the current evidence on the association between intestinal microbiota and obesity. Additionally, we analyze the effects of an extreme weight loss intervention such as bariatric surgery on gut microbiota. The review is divided into 2 sections: first, the association of obesity and related metabolic disorders with different gut microbiome profiles, including metagenomics studies, and second, changes on gut microbiome after an extreme weight loss intervention such as bariatric surgery.
ISSN:1687-8337
1687-8345
DOI:10.1155/2018/4095789