Management of Melanoma in Elderly Patients over 80 Years

Melanoma is a malignant tumour with a poorer prognosis in stage III and IV patients. Development of effective therapies for the treatment of advanced melanoma has led to an improvement in survival. Furthermore, the French population is ageing, and treatment of melanoma in this population has several...

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Bibliographic Details
Published in:Acta dermato-venereologica 2024-11, Vol.104, p.adv41029
Main Authors: Jourdain, Héloïse, Lavaud, Justine, Descours, Clémentine, Auditeau, Emilie, Bernard, Philippe
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Chemotherapy, Adjuvant
Dermatologic Surgical Procedures - adverse effects
elderly
Female
France - epidemiology
Humans
initial staging
Male
melanoma
Melanoma - mortality
Melanoma - pathology
Melanoma - secondary
Melanoma - surgery
Melanoma - therapy
Middle Aged
Neoplasm Staging
Original Report
Retrospective Studies
Sentinel Lymph Node Biopsy
Skin Neoplasms - mortality
Skin Neoplasms - pathology
Skin Neoplasms - therapy
treatment
Treatment Outcome
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Summary:Melanoma is a malignant tumour with a poorer prognosis in stage III and IV patients. Development of effective therapies for the treatment of advanced melanoma has led to an improvement in survival. Furthermore, the French population is ageing, and treatment of melanoma in this population has several specific limitations. This descriptive, retrospective, single-centre study collected data on the diagnostic and therapeutic management of patients with melanoma of Breslow ≥ 1 mm or of unknown primary and metastatic spread, at Limoges University Hospital, between 2018 and 2022, and compared the results obtained between 2 groups: under 80 and over 80 years of age; 344 patients were included. The extension work-up was more frequently complete and the sentinel lymph node technique more frequently performed in patients under 80. Wide excision was more frequently in accordance with guidelines in patients over 80. Adjuvant or first-line metastatic treat-ment was more frequently instituted in patients under 80, but no difference was found as regards the second and third lines, the frequency of adverse events, and the reason for stopping treatment. Our study supports similar management of elderly and young subjects, given the safety profile and efficacy of treatments.
ISSN:0001-5555
1651-2057
1651-2057
DOI:10.2340/actadv.v104.41029