Temporal change in inflammatory biomarkers and risk of cardiovascular events: the Multi‐ethnic Study of Atherosclerosis

Aims Little is known about the association of temporal changes in inflammatory biomarkers and the risk of death and cardiovascular diseases. We aimed to evaluate the association between temporal changes in C‐reactive protein (CRP), fibrinogen, and interleukin‐6 (IL‐6) and risk of heart failure (HF),...

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Bibliographic Details
Published in:ESC Heart Failure 2021-10, Vol.8 (5), p.3769-3782
Main Authors: Shabani, Mahsima, Bakhshi, Hooman, Ostovaneh, Mohammad R., Ma, Xiaoyang, Wu, Colin O., Ambale‐Venkatesh, Bharath, Blaha, Michael J., Allison, Matthew A., Budoff, Matthew J., Cushman, Mary, Tracy, Russell P., Herrington, David M., Szklo, Moyses, Cox, Christopher, Bluemke, David A., Lima, João A.C.
Format: Article
Language:English
Subjects:
Angina pectoris
Antihypertensives
Atherosclerosis
Biomarkers
Cardiovascular disease
Cardiovascular Diseases - epidemiology
Chinese Americans
Cohort analysis
Cohort Studies
C‐reactive protein
Diabetes
Ethnicity
Female
Fibrinogen
Heart failure
Hispanic people
Humans
Hypertension
Hypothesis testing
Interleukin
Laboratories
Longitudinal cohort study
Male
Middle Aged
Mortality
Original
Original s
Risk factors
Survival analysis
Womens health
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Summary:Aims Little is known about the association of temporal changes in inflammatory biomarkers and the risk of death and cardiovascular diseases. We aimed to evaluate the association between temporal changes in C‐reactive protein (CRP), fibrinogen, and interleukin‐6 (IL‐6) and risk of heart failure (HF), cardiovascular disease (CVD), and all‐cause mortality in individuals without a history of prior CVD. Methods and results Participants from the Multi‐Ethnic Study of Atherosclerosis (MESA) cohort with repeated measures of inflammatory biomarkers and no CVD event prior to the second measure were included. Quantitative measures, annual change, and biomarker change categories were used as main predictors in Cox proportional hazard models stratified based on sex and statin use. A total of 2258 subjects (50.6% female, mean age of 62 years) were studied over an average of 8.1 years of follow‐up. The median annual decrease in CRP levels was 0.08 mg/L. Fibrinogen and IL‐6 levels increased by a median of 30 mg/dL and 0.24 pg/mL annually. Temporal changes in CRP were positively associated with HF risk among females (HR: 1.18 per each standard deviation increase, P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13445