Recruitment and retention of the participants in clinical trials: Challenges and solutions

Drug development is a tedious and expensive procedure and it takes roughly 10 to 15 years to take a potential treatment from bench to bedside and costs the pharmaceutical companies as much as USD ~2 billion for the process. Delay in investigator-initiated studies can cause financial loss to grant pr...

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Bibliographic Details
Published in:Perspectives in clinical research 2020-04, Vol.11 (2), p.64-69
Main Authors: Chaudhari, Nayan, Ravi, Renju, Gogtay, Nithya, Thatte, Urmila
Format: Article
Language:English
Subjects:
clinical studies
Clinical trials
Drug development
Fear & phobias
Finance
Gender
Hospitals
Investigator Insights
Laboratories
Literature reviews
Medical research
Medical research volunteers
Methods
nonadherence
Participation
Patients
Pharmaceutical industry
Planning
Recruiting
recruiting participants
Researchers
Retention
Socioeconomic factors
Studies
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Summary:Drug development is a tedious and expensive procedure and it takes roughly 10 to 15 years to take a potential treatment from bench to bedside and costs the pharmaceutical companies as much as USD ~2 billion for the process. Delay in investigator-initiated studies can cause financial loss to grant providers (either public or private) and investigator's reputation may also be at stake. Participant recruitment and retention are two major bottlenecks in conducting clinical trials and contribute vastly to the delays. They are essential for both scientific validity of the clinical study and economic reasons. Thus, issues in recruitment and retention should be addressed and minimized. A proper recruitment and retention plan incorporating adequate communication between all stakeholders will eventually avoid the delays in drug development and make treatments available to the consumer at an earlier date and at a more affordable price. Awareness of challenges and reviewing strategies that can optimise recruitment and retention will facilitate drug development. The article gives a first-person perspective on challenges and proposed solutions from an experienced clinical study centre in a tertiary care hospital.
ISSN:2229-3485
2229-5488
DOI:10.4103/picr.PICR_206_19