Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy

Background Chronic Chagas cardiomyopathy in humans is characterized by segmental left ventricular wall motion abnormalities (WMA), mainly in the early stages of disease. This study aimed at investigating the detection of WMA and its correlation with the underlying histopathological changes in a chro...

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Bibliographic Details
Published in:Journal of the American Heart Association 2016-01, Vol.5 (1), p.n/a
Main Authors: Oliveira, Luciano Fonseca Lemos, Romano, Minna Moreira Dias, Carvalho, Eduardo Elias Vieira, Mejia Cabeza, Jorge, Salgado, Hélio Cesar, Fazan Júnior, Rubens, Costa, Renata Sesti, Silva, João Santana, Lourdes Higuchi, Maria, Maciel, Benedito Carlos, Cunha‐Neto, Edécio, Marin‐Neto, José Antônio, Simões, Marcus Vinícius
Format: Article
Language:English
Subjects:
Animals
Chagas Cardiomyopathy - diagnostic imaging
Chagas Cardiomyopathy - parasitology
Chagas Cardiomyopathy - pathology
Chagas Cardiomyopathy - physiopathology
Chagas heart failure
Chronic Disease
Disease Models, Animal
echocardiography
Echocardiography, Doppler
Female
Fibrosis
Mesocricetus
Myocardium - pathology
Original Research
pathology
Stroke Volume
Systole
Time Factors
Trypanosoma cruzi - pathogenicity
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - parasitology
Ventricular Dysfunction, Left - pathology
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left
Ventricular Remodeling
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Summary:Background Chronic Chagas cardiomyopathy in humans is characterized by segmental left ventricular wall motion abnormalities (WMA), mainly in the early stages of disease. This study aimed at investigating the detection of WMA and its correlation with the underlying histopathological changes in a chronic Chagas cardiomyopathy model in hamsters. Methods and Results Female Syrian hamsters (n=34) infected with 3.5×104 or 105 blood trypomastigote Trypanosoma cruzi (Y strain) forms and an uninfected control group (n=7) were investigated. After 6 or 10 months after the infection, the animals were submitted to in vivo evaluation of global and segmental left ventricular systolic function by echocardiography, followed by euthanasia and histological analysis for quantitative assessment of fibrosis and inflammation with tissue sampling in locations coinciding with the left ventricular wall segmentation employed at the in vivo echocardiographic evaluation. Ten of the 34 infected animals (29%) showed reduced left ventricular ejection fraction (
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.115.002786