Determination of drug-related problems among type 2 diabetes outpatients in a hospital in Vietnam: A cross-sectional study

• Published in: PloS one 2023-01, Vol.18 (8)
• Main Authors: Duong Thi Ly Huong, Nguyen Thanh Hang, Nguyen Khanh Ly, Nguyen Hong Nhat, Nguyen Thi Lan Huong, Le Thi Phuong Hue, Dang Thi Lan Anh, Bui Thi Kim Dung, Phung Minh Phuong, Luong Thuy Lan, Truong Thanh Tung, Nguyen Ngoc Hieu, Ngo Hai Ly
• Format: Article
• Language: English
• ISSN: 1932-6203

Introduction Drug-related problems (DRPs) are common in clinical practice and occur at all stages of the medication process. The major factor contributing to DRPs is prescription, although patients’ poor adherence to treatment is also a significant factor. This study evaluated type 2 diabetes outpatients in a hospital in Vietnam for drug-related problems (DRPs) and related variables. Methods A cross-sectional descriptive study was conducted on 495 outpatients who met the criteria and 157 people agreed to participate in the interview. Medication order review and medication adherence review were used to identify DRPs. The types of DRP were based on the Pharmaceutical Care Network Europe (PCNE) categories version 9.0. The identification and assessment DRPs were carried out by clinical pharmacists and get agreed upon by physicians who had not directly prescribed patients who participated in the study. Results A total of 762 DRPs were identified via prescribing review process, the average number of DRP on each prescription was 1.54±1.07, while 412 DRPs were determined through patient interviewing. The most frequent DRPs were “ADR (Adverse Drug Reaction) occurring” (68.8%). The main causes were “patient is unable to understand instructions properly” or “patient is not properly instructed”, “patient stores insulin inappropriately”, “patient decides to use unnecessary drugs” and “patient intentionally uses/takes less drug than prescribed or does not take the drug at all for whatever reason” which accounted for 65.0%, 41.4%, 38.2%, and 28.7%, respectively. From the prescribing review, the most observed DRPs were “Inappropriate drug according to guidelines/formulary” and “No or incomplete drug treatment in spite of existing indication”, accounting for 45.0% and 42.9%, respectively. There was a significant association between age (OR 3.38, 95% CI: 1.01–11.30), duration of diabetes (OR 3.61, 95%CI: 1.11–11.74), presence of comorbidity (OR 5.31, 95%CI: 1.97–14.30), polypharmacy (OR: 2.95, 95%CI: 1.01–8.72) and DRPs. In patients, poor knowledge of antidiabetic agents was the main reason to lack adherence and occurring ADR (OR 2.73, 95%CI: 1.32–5.66, p = 0.007 and OR 2.49, 95%CI: 1.54–4.03, p = 0.001 respectively). Conclusion DRPs occurred in the prescribing stage and relating to patient’s behavior of drug administration was high. Clear identification of DRPs and the associated factors are essential for building the intervention process to improve effectiveness and safet