The effects of flow settings during high-flow nasal cannula oxygen therapy for neonates and young children

• Published in: European respiratory review 2024-01, Vol.33 (171), p.230223
• Main Authors: Li, Jie, Deng, Ni, He, Wan Jia Aaron, Yang, Cui, Liu, Pan, Albuainain, Fai A, Ring, Brian J, Miller, Andrew G, Rotta, Alexandre T, Guglielmo, Robert D, Milési, Christophe
• Format: Article
• Language: English
• Subjects: Age Factors; Cannula; Child, Preschool; Humans; Infant; Infant, Newborn; Lung - physiopathology; Oxygen - administration & dosage; Oxygen Inhalation Therapy - instrumentation; Oxygen Inhalation Therapy - methods; Reviews; Treatment Outcome
• ISSN: 0905-9180; 1600-0617; 1600-0617
• DOI: 10.1183/16000617.0223-2023

During neonatal and paediatric high-flow nasal cannula therapy, optimising the flow setting is crucial for favourable physiological and clinical outcomes. However, considerable variability exists in clinical practice regarding initial flows and subsequent adjustments for these patients. Our review aimed to summarise the impact of various flows during high-flow nasal cannula treatment in neonates and children. Two investigators independently searched PubMed, Embase, Web of Science, Scopus and Cochrane for and studies published in English before 30 April 2023. Studies enrolling adults (≥18 years) or those using a single flow setting were excluded. Data extraction and risk of bias assessments were performed independently by two investigators. The study protocol was prospectively registered with PROSPERO (CRD42022345419). 38 406 studies were identified, with 44 included. studies explored flow settings' effects on airway pressures, humidity and carbon dioxide clearance; all were flow-dependent. Observational clinical studies consistently reported that higher flows led to increased pharyngeal pressure and potentially increased intrathoracic airway pressure (especially among neonates), improved oxygenation, and reduced respiratory rate and work of breathing up to a certain threshold. Three randomised controlled trials found no significant differences in treatment failure among different flow settings. Flow impacts exhibited significant heterogeneity among different patients. Individualising flow settings in neonates and young children requires consideration of the patient's peak inspiratory flow, respiratory rate, heart rate, tolerance, work of breathing and lung aeration for optimal care.