Ankle Brachial Index and Subsequent Cardiovascular Disease Risk in Patients With Chronic Kidney Disease

Background The clinical implications of ankle‐brachial index (ABI) cutpoints are not well defined in patients with chronic kidney disease (CKD) despite increased prevalence of high ABI attributed to arterial stiffness. We examined the relationship of ABI with cardiovascular disease (CVD) and all‐cau...

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Bibliographic Details
Published in:Journal of the American Heart Association 2016-06, Vol.5 (6), p.n/a
Main Authors: Chen, Jing, Mohler, Emile R., Garimella, Pranav S., Hamm, L. Lee, Xie, Dawei, Kimmel, Stephen, Townsend, Raymond R., Budoff, Matthew, Pan, Qiang, Nessel, Lisa, Steigerwalt, Susan, Wright, Jackson T., He, Jiang, Appel, Lawrence J., Feldman, Harold I., Go, Alan S., Kusek, John W., Lash, James P., Ojo, Akinlolu, Rahman, Mahboob
Format: Article
Language:English
Subjects:
Adult
Aged
Ankle Brachial Index
Blood Pressure - physiology
cardiovascular disease
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Cardiovascular Diseases - physiopathology
chronic kidney disease
Female
Glomerular Filtration Rate - physiology
heart failure
Heart Failure - etiology
Heart Failure - mortality
Heart Failure - physiopathology
Humans
Kaplan-Meier Estimate
Male
Middle Aged
mortality
myocardial infarction
Myocardial Infarction - etiology
Myocardial Infarction - mortality
Myocardial Infarction - physiopathology
Original Research
peripheral arterial disease
Peripheral Arterial Disease - etiology
Peripheral Arterial Disease - mortality
Peripheral Arterial Disease - physiopathology
Prospective Studies
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - mortality
Renal Insufficiency, Chronic - physiopathology
Risk Factors
Young Adult
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Summary:Background The clinical implications of ankle‐brachial index (ABI) cutpoints are not well defined in patients with chronic kidney disease (CKD) despite increased prevalence of high ABI attributed to arterial stiffness. We examined the relationship of ABI with cardiovascular disease (CVD) and all‐cause mortality among CKD patients. Methods and Results Three thousand six hundred twenty‐seven participants without clinical peripheral artery disease (PAD) at baseline from the Chronic Renal Insufficiency Cohort Study were included. ABI was obtained per standard protocol and CVD events were confirmed by medical record adjudication. A U‐shaped association of ABI with PAD, myocardial infarction (MI), composite CVD, and all‐cause mortality was observed. Individuals with an ABI between 1.0 and
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.116.003339