Ectopy on a Single 12‐Lead ECG, Incident Cardiac Myopathy, and Death in the Community

• Published in: Journal of the American Heart Association 2017-08, Vol.6 (8), p.n/a
• Main Authors: Nguyen, Kaylin T., Vittinghoff, Eric, Dewland, Thomas A., Dukes, Jonathan W., Soliman, Elsayed Z., Stein, Phyllis K., Gottdiener, John S., Alonso, Alvaro, Chen, Lin Y., Psaty, Bruce M., Heckbert, Susan R., Marcus, Gregory M.
• Format: Article
• Language: English
• Subjects: Aged; atrial fibrillation; Atrial Fibrillation - mortality; Atrial Premature Complexes - mortality; Cardiomyopathies - mortality; Electrocardiography; Female; heart failure; Heart Failure - mortality; Humans; Incidence; Male; Middle Aged; mortality; Original Research; premature atrial contractions; premature ventricular contractions; Prognosis; Prospective Studies; Risk Factors; United States - epidemiology; Ventricular Premature Complexes - mortality
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.117.006028

Background Atrial fibrillation and heart failure are 2 of the most common diseases, yet ready means to identify individuals at risk are lacking. The 12‐lead ECG is one of the most accessible tests in medicine. Our objective was to determine whether a premature atrial contraction observed on a standard 12‐lead ECG would predict atrial fibrillation and mortality and whether a premature ventricular contraction would predict heart failure and mortality. Methods and Results We utilized the CHS (Cardiovascular Health) Study, which followed 5577 participants for a median of 12 years, as the primary cohort. The ARIC (Atherosclerosis Risk in Communities Study), the replication cohort, captured data from 15 792 participants over a median of 22 years. In the CHS, multivariable analyses revealed that a baseline 12‐lead ECG premature atrial contraction predicted a 60% increased risk of atrial fibrillation (hazard ratio, 1.6; 95% CI, 1.3–2.0; P