The association between organophosphate insecticides and blood pressure dysregulation: NHANES 2013–2014

Background Organophosphate (OP) insecticides represent one of the largest classes of sprayed insecticides in the U.S., and their use has been associated with various adverse health outcomes, including disorders of blood pressure regulation such as hypertension (HTN). Methods In a study of 935 adults...

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Bibliographic Details
Published in:Environmental health 2022-08, Vol.21 (1), p.1-74, Article 74
Main Authors: Glover, Frank, Eisenberg, Michael L., Belladelli, Federico, Del Giudice, Francesco, Chen, Tony, Mulloy, Evan, Caudle, W. Michael
Format: Article
Language:English
Subjects:
Alcohol use
Bans
Biodegradation
Blood pressure
Chemicals
Chlorpyrifos
Data collection
Diabetes
Diazinon
Dioxins
Endocrine disruption
Environmental health
Enzymes
Etiology
Fungicides
Hypertension
Insecticides
Insurance coverage
Interviews
Laboratories
Metabolites
Methyl parathion
Minority & ethnic groups
Nitrophenol
Nutrition research
Organophosphates
p-Nitrophenol
Parathion
PCB
Pediatrics
Pesticides
Polychlorinated biphenyls
Population
Public health
Quartiles
Questionnaires
Regression analysis
Risk assessment
Trichloro-2-pyridinol
Urine
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Summary:Background Organophosphate (OP) insecticides represent one of the largest classes of sprayed insecticides in the U.S., and their use has been associated with various adverse health outcomes, including disorders of blood pressure regulation such as hypertension (HTN). Methods In a study of 935 adults from the NHANES 2013–2014 cycle, we examined the relationship between systolic and diastolic blood pressure changes and urinary concentrations of three OP insecticides metabolites, including 3,5,6-trichloro-2-pyridinol (TCPy), oxypyrimidine, and para-nitrophenol. These metabolites correspond to the parent compounds chlorpyrifos, diazinon, and methyl parathion, respectively. Weighted, multivariable linear regression analysis while adjusting for potential confounders were used to model the relationship between OP metabolites and blood pressure. Weighted, multivariable logistic regression analysis was used to model the odds of HTN for quartile of metabolites. Results We observed significant, inverse association between TCPy on systolic blood pressure (β-estimate = -0.16, p 
ISSN:1476-069X
1476-069X
DOI:10.1186/s12940-022-00887-3