Elevated gut microbiota metabolite bile acids confer protective effects on clinical prognosis in ischemic stroke patients

There is evidence of an association between the gut microbiota and progression of stroke. However, the relationship between gut microbial metabolites, specifically bile acids (BAs), and post-ischemic stroke disability and poor functional outcomes remains unexplored. Patients with acute ischemic stro...

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Published in:Frontiers in neuroscience 2024-04, Vol.18, p.1388748-1388748
Main Authors: Wang, Zhaobin, Li, Jing, Xu, Yingxin, Liu, Ye, Zhang, Zhe, Xu, Qin, Lin, Jinxi, Jiang, Yong, Wang, Yongjun, Jing, Jing, Wang, Anxin, Meng, Xia
Format: Article
Language:English
Subjects:
bile acids
gut microbiota metabolite
gut-brain axis
Neuroscience
poor functional outcome
stroke
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Summary:There is evidence of an association between the gut microbiota and progression of stroke. However, the relationship between gut microbial metabolites, specifically bile acids (BAs), and post-ischemic stroke disability and poor functional outcomes remains unexplored. Patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA) in the Third China National Stroke Registry were grouped according to total bile acid (TBA) quartile on admission. Association of TBA with disability and poor functional outcomes were evaluated using logistic regression models and restricted cubic splines. Data for 9,536 patients were included. After adjusting for confounders, the risks of disability and poor functional outcomes were significantly lower in the highest TBA quartile than in the lowest TBA quartile at the 3-month follow-up, with respective odds ratios (ORs) of 0.65 (95% confidence interval [CI] 0.55-0.78;  
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2024.1388748