Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice

• Published in: Drug design, development and therapy development and therapy, 2019-10, Vol.13, p.3657-3667
• Main Authors: Zhu, Ye, Li, Ze-Liang, Ding, Ao, Yang, Hui, Zhu, Wei-Ping, Cui, Tong-Xia, Zhang, Hui-Tao, Zhang, Hua
• Format: Article
• Language: English
• Subjects: Aangiotensin II; Albumin; Albumins; Albuminuria - drug therapy; Analysis; Angiotensin; Angiotensin II; Angiotensin II Type 1 Receptor Blockers - pharmacology; Angiotensins; Animal models; Animals; Biochemistry; Chronic kidney failure; Creatinine; Creatinine - blood; db/db mice; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Nephropathies - drug therapy; Diabetic Nephropathies - physiopathology; Diabetic nephropathy; Disease Progression; Drug dosages; EDTA; End-stage renal disease; Enzymes; Glucose; Hospitals; Hypertension; Hypertrophy; Injury prevention; Kidney diseases; Male; Mathematical models; Metabolism; Metabolites; Mice; Nephrology; Nephropathy; Olmesartan medoxomil; Olmesartan Medoxomil - pharmacology; Original Research; Oxidative stress; Parameters; Physiological aspects; Physiology; Renal function; Renal injury; Rodents; Streptozocin; Type 2 diabetes; Urine
• ISSN: 1177-8881; 1177-8881
• DOI: 10.2147/DDDT.S217826

Diabetic nephropathy (DN) is a common complication of diabetes mellitus (DM) and also a major cause of end-stage renal disease (ESRD). Olmesartan medoxomil (OM) is an angiotensin II receptor blocker (ARB) and has been shown to exhibit renoprotective effects on a streptozotocin (STZ)-induced diabetic rat model. Yet, whether OM affects DN progression and renal injury in db/db mice, a type 2 diabetic murine model, has not been established. Wild-type (n = 15) and db/db mice (n = 15) were treated with control saline or OM via oral gavage. The physiological and biochemical parameters were evaluated and histological examinations of kidney specimens were performed. Compared with saline-treated db/db mice, db/db mice administered with OM showed ameliorated diabetic physiological and biochemical parameters. In addition, OM decreased urinary albumin excretion and plasma creatinine level in db/db mice. Moreover, histologically, OM reduced glomerular hypertrophy and injury, and also ameliorated tubular injury, thus suggesting that OM improves renal function and minimizes renal pathological deterioration in db/db mice. Our study reveals a beneficial role of OM in ameliorating DN in db/db mice, which is associated with its renoprotective function.