Temporal and spatial resolution of magnetosome degradation at the subcellular level in a 3D lung carcinoma model

Magnetic nanoparticles offer many exciting possibilities in biomedicine, from cell imaging to cancer treatment. One of the currently researched nanoparticles are magnetosomes, magnetite nanoparticles of high chemical purity synthesized by magnetotactic bacteria. Despite their therapeutic potential,...

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Published in:Journal of nanobiotechnology 2024-09, Vol.22 (1), p.529-14, Article 529
Main Authors: Gubieda, Alicia G, Gandarias, Lucía, Pósfai, Mihály, Pattammattel, Ajith, Fdez-Gubieda, M Luisa, Abad-Díaz-de-Cerio, Ana, García-Prieto, Ana
Format: Article
Language:English
Subjects:
Biodegradation
Biomineralisation
Cancer
Cancer cells
Carcinoma
Care and treatment
Cell Line, Tumor
Cell organelles
Cells
Drug delivery systems
Drugs
Ferric Compounds - chemistry
Ferric Compounds - metabolism
Ferritin
Ferritins - chemistry
Ferritins - metabolism
Ferrosoferric Oxide - chemistry
Health aspects
Humans
Lung cancer
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Magnetic nanoparticle degradation
Magnetic properties
Magnetite
Magnetite Nanoparticles - chemistry
Magnetosome
Magnetosomes - chemistry
Magnetosomes - metabolism
MATERIALS SCIENCE
Nano-XANES
Nano-XRF
Nanoparticles
Oxidation-Reduction
Physiological aspects
Therapeutics, Experimental
Vehicles
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Summary:Magnetic nanoparticles offer many exciting possibilities in biomedicine, from cell imaging to cancer treatment. One of the currently researched nanoparticles are magnetosomes, magnetite nanoparticles of high chemical purity synthesized by magnetotactic bacteria. Despite their therapeutic potential, very little is known about their degradation in human cells, and even less so of their degradation within tumours. In an effort to explore the potential of magnetosomes for cancer treatment, we have explored their degradation process in a 3D human lung carcinoma model at the subcellular level and with nanometre scale resolution. We have used state of the art hard X-ray probes (nano-XANES and nano-XRF), which allow for identification of distinct iron phases in each region of the cell. Our results reveal the progression of magnetite oxidation to maghemite within magnetosomes, and the biosynthesis of magnetite and ferrihydrite by ferritin.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-024-02788-8