Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates

The formation of new neurons in the adult central nervous system (CNS) has been recognized as one of the major findings in neuroanatomical research. The hippocampal formation (HF), one of the main targets of these investigations, holds a neurogenic niche widely recognized among several mammalian spe...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in neuroanatomy 2018-06, Vol.12, p.44-44
Main Authors: Baptista, Pedro, Andrade, José P
Format: Article
Language:English
Subjects:
Aging
Anatomy
Brain
Brain architecture
Cell adhesion & migration
Cell proliferation
Cell survival
Central nervous system
cognition
Cognitive ability
dentate gyrus
hippocampal formation
Hippocampus
man
memory
Mental depression
Mental disorders
Neurogenesis
Neurons
Neuroscience
Neurosciences
Older people
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The formation of new neurons in the adult central nervous system (CNS) has been recognized as one of the major findings in neuroanatomical research. The hippocampal formation (HF), one of the main targets of these investigations, holds a neurogenic niche widely recognized among several mammalian species and whose existence in the human brain has sparked controversy and extensive debate. Many cellular features from this region emphasize that hippocampal neurogenesis suffers changes with normal aging and, among regulatory factors, physical exercise and chronic stress provoke opposite effects on cell proliferation, maturation and survival. Considering the numerous functions attributable to the HF, increasing or decreasing the integration of new neurons in the delicate neuronal network might be significant for modulation of cognition and emotion. The role that immature and mature adult-born neurons play in this circuitry is still mostly unknown but it could prove fundamental to understand hippocampal-dependent cognitive processes, the pathophysiology of depression, and the therapeutic effects of antidepressant medication in modulating behavior and mental health.
ISSN:1662-5129
1662-5129
DOI:10.3389/fnana.2018.00044