Hypervalent iodine-mediated intramolecular alkene halocyclisation

The chemistry of hypervalent iodine (HVI) reagents has gathered increased attention towards the synthesis of a wide range of chemical structures. HVI reagents are characterized by their diverse reactivity as oxidants and electrophilic reagents. In addition, they are inexpensive, non-toxic and consid...

Full description

Saved in:
Bibliographic Details
Published in:Beilstein journal of organic chemistry 2024-11, Vol.20 (1), p.3113-3133
Main Authors: Bansal, Charu, Ruggles, Oliver, Rowett, Albert C, Lennox, Alastair J J
Format: Article
Language:English
Subjects:
Chemistry
cyclisation
halogenation
heterocycles
hypervalent iodine
oxidation
Review
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The chemistry of hypervalent iodine (HVI) reagents has gathered increased attention towards the synthesis of a wide range of chemical structures. HVI reagents are characterized by their diverse reactivity as oxidants and electrophilic reagents. In addition, they are inexpensive, non-toxic and considered to be environmentally friendly. An important application of HVI reagents is the synthesis of halogenated cyclic compounds, in particular, the intramolecular HVI-mediated halocyclisation of alkenes using carbon, oxygen, nitrogen or sulfur nucleophiles. Herein, we describe the examples reported in the literature, which are organised by the different halogens involved and the internal nucleophiles.
ISSN:1860-5397
1860-5397
DOI:10.3762/bjoc.20.258