Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective

A common malignant bone neoplasm in teenagers is Osteosarcoma. Chemotherapy, surgical therapy, and radiation therapy together comprise the usual clinical course of treatment for Osteosarcoma. While Osteosarcoma and other bone tumors are typically treated surgically, however, surgical resection frequ...

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Bibliographic Details
Published in:Drug delivery 2024-12, Vol.31 (1), p.2391001
Main Authors: Liang, Wenqing, Long, Hengguo, Zhang, Hongwei, Bai, Juqin, Jiang, Bo, Wang, Jiangwei, Fu, Lifeng, Ming, Wenyi, Zhao, Jiayi, Zeng, Bin
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacology
Bone and Bones - drug effects
Bone cancer
Bone Neoplasms - drug therapy
Chemotherapy
drug delivery systems
Drug Delivery Systems - methods
Humans
localized bone scaffolds
natural polymers
Osteosarcoma
Osteosarcoma - drug therapy
Radiation
Review
synthetic polymers
Tissue Scaffolds
Tumors
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Summary:A common malignant bone neoplasm in teenagers is Osteosarcoma. Chemotherapy, surgical therapy, and radiation therapy together comprise the usual clinical course of treatment for Osteosarcoma. While Osteosarcoma and other bone tumors are typically treated surgically, however, surgical resection frequently fails to completely eradicate tumors, and in turn becomes the primary reason for postoperative recurrence and metastasis, ultimately leading to a high rate of mortality. Patients still require radiation and/or chemotherapy after surgery to stop the spread of the tumor and its metastases, and both treatments have an adverse influence on the body's organ systems. In the postoperative management of osteosarcoma, bone scaffolds can load cargos (growth factors or drugs) and function as drug delivery systems (DDSs). This review describes the different kinds of bone scaffolds that are currently available and highlights key studies that use scaffolds as DDSs for the treatment of osteosarcomas. The discussion also includes difficulties and perspectives regarding the use of scaffold-based DDSs. The study may serve as a source for outlining efficient and secure postoperative osteosarcoma treatment plans.
ISSN:1071-7544
1521-0464
1521-0464
DOI:10.1080/10717544.2024.2391001