Novel oral anticoagulant use in adults with congenital heart disease: a single-center experience report

• Published in: The Egyptian heart journal 2023-01, Vol.75 (1), p.3-3, Article 3
• Main Authors: Samarai, Daniel, Isma, Nazim, Lindstedt, Sandra, Hlebowicz, Joanna
• Format: Article
• Language: English
• Subjects: Adults; Age; Anticoagulants; Anticoagulants (Medicine); Atrial fibrillation; Cardiac and Cardiovascular Systems; Cardiac arrhythmia; Cardiology; Cardiovascular disease; Care and treatment; Clinical Medicine; Congenital diseases; Congenital heart disease; Diabetes; Genetic disorders; Heart; Hypertension; Kardiologi; Klinisk medicin; Medical and Health Sciences; Medical records; Medical research; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Medicine, Experimental; Novel oral anticoagulants; Patients; Review boards; Stroke; Thromboembolism; Thrombosis; Transient ischemic attack
• ISSN: 2090-911X; 1110-2608; 2090-911X
• DOI: 10.1186/s43044-022-00326-1

Background Adults with congenital heart disease (ACHD) are a group with an increased risk of thromboembolic complications and arrhythmias. Vitamin K antagonists are the most commonly used thromboprophylaxis therapy in this population. Studies on the efficacy and safety of novel oral anticoagulants (NOAC) are scare in ACHD. A retrospective study on ACHD patients on NOAC treatment registered in the National Quality Registry for Congenital Heart Disease, SWEDCON, and National Quality Registry for Atrial fibrillation and Anticoagulation, AuriculA, from Southern Sweden. Results Thirty patients who had been taking NOAC treatment for a minimum of 3 months were included. Their median age was 55 years (SD 17 years) and 57% were male. Median follow-up was 17 months (IQR: 10–41). Eliquis was the most used NOAC (47%). Median CHA 2 DS 2 -VASc score was 2 (IQR: 0–3) and HAS-BLED was 1 (IQR: 0–2). Complex ACHD was prevalent in 27% of the patients. No thromboembolic events were recorded; however, one major bleeding, unspecified, was reported during the total cumulative patient follow-up time of 64 years. Conclusions The results of our study, although limited in size, suggest that NOAC appear safe and effective in ACHD patients. Further and larger studies on NOAC in ACHD patients are warranted.