Metabolomic Differentials in Women With and Without Fibromyalgia

A nontargeted plasma metabolomic analysis was conducted to compare differentially expressed metabolites in women with and without fibromyalgia (FM) using data and samples collected from two parent studies in women with FM (n = 20) and comparative data collected from newly recruited age‐matched women...

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Bibliographic Details
Published in:Clinical and translational science 2020-01, Vol.13 (1), p.67-77
Main Authors: Menzies, Victoria, Starkweather, Angela, Yao, Yingwei, Thacker, Leroy R., Garrett, Timothy J., Swift‐Scanlan, Theresa, Kelly, Debra Lynch, Patel, Param, Lyon, Debra E.
Format: Article
Language:English
Subjects:
Age
Ambulatory care
Amino acids
Biomarkers
Blood plasma
Data collection
Fibromyalgia
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Metabolism
Metabolites
Metabolomics
Oxidative stress
Pain
Physiology
Researchers
Retention
Rheumatology
Scientific imaging
Statistical analysis
Studies
Tryptophan
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Summary:A nontargeted plasma metabolomic analysis was conducted to compare differentially expressed metabolites in women with and without fibromyalgia (FM) using data and samples collected from two parent studies in women with FM (n = 20) and comparative data collected from newly recruited age‐matched women (n = 20). Blood plasma samples were analyzed for metabolite content using liquid chromatography mass spectrometry. Consolidation of positive and negative ion mode metabolomics data with fold change (>2 or
ISSN:1752-8054
1752-8062
DOI:10.1111/cts.12679