Designing Green Synthesis-Based Silver Nanoparticles for Antimicrobial Theranostics and Cancer Invasion Prevention

• Published in: International journal of nanomedicine 2024-01, Vol.19, p.4451-4464
• Main Authors: Alomar, Taghrid S, AlMasoud, Najla, Awad, Manal A, AlOmar, Reem S, Merghani, Nada M, El-Zaidy, Mohamed, Bhattarai, Ajaya
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biological products; Cancer; Cell Line, Tumor; Crystals; dynamic light scattering; Electrons; Escherichia coli; Escherichia coli - drug effects; Ethylenediaminetetraacetic acid; Green Chemistry Technology - methods; Green design; Humans; Infrared spectroscopy; Light; Metal Nanoparticles - chemistry; Microbial Sensitivity Tests; Nanoparticles; Neoplasm Invasiveness - prevention & control; Neoplasms - drug therapy; Neoplasms - pathology; Particle Size; Photoluminescence; Plant Extracts - chemistry; Plant Extracts - pharmacology; Rifaximin; Silver; Silver - chemistry; Silver - pharmacology; silver nanoparticles; Spectroscopy, Fourier Transform Infrared; Spectrum analysis; Staphylococcus aureus - drug effects; Structure; Theranostic Nanomedicine - methods; transmission peak; uv-vis spectroscopy
• ISSN: 1178-2013; 1178-2013
• DOI: 10.2147/IJN.S440847

Researchers are increasingly favouring the use of biological resources in the synthesis of metallic nanoparticles. This synthesis process is quick and affordable. The current study examined the antibacterial and anticancer effects of silver nanoparticles (AgNPs) derived from the plant. Biomolecules derived from natural sources can be used to coat AgNPs to make them biocompatible. UV-Vis spectroscopy was used to verify the synthesis of AgNPs from plant extract, while transmission electron microscopy (TEM), photoluminescence (PL) spectroscopy, dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR) were used to characterize their morphology, crystalline structure, stability, and coating. UV-visible spectrum of AgNPs shows an absorption peak at 422 nm, indicating the isotropic nature of these nanoparticles. As a result of the emergence of a transmission peak at 804.53 and 615.95 cm in the spectrum of the infrared light emitted by atoms in a sample, FTIR spectroscopy demonstrated that the Ag stretching vibration mode is metal-oxygen (M-O). Electron dispersive X-ray (EDX) spectral analysis shows that elementary silver has a peak at 3 keV. Irradiating the silver surface with electrons, photons, or laser beams triggers the illumination. The emission peak locations have been found between 300 and 550 nm. As a result of DLS analysis, suspended particles showed a bimodal size distribution, with their Z-average particle size being 93.38 nm. The findings showed that the antibacterial action of AgNPs was substantially ( ≤0.05) more evident against than . The biosynthesis of AgNPs is an environmentally friendly method for making nanostructures that have antimicrobial and anticancer properties.