Associations between ethylene oxide exposure and biological age acceleration: evidence from NHANES 2013-2016

Population aging is a global concern, with the World Health Organization predicting that by 2030, one in six individuals worldwide will be 60 years or older. Ethylene oxide (EO) is a widely used industrial chemical with potential health risks, including associations with age-related diseases. This s...

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Bibliographic Details
Published in:Frontiers in public health 2024-11, Vol.12, p.1488558
Main Authors: Chen, Xinyun, Shi, Fangyu, Yu, Wenhui, He, Chunying, Gou, Shenju, Fu, Ping
Format: Article
Language:English
Subjects:
Adult
Aged
Aging
biological aging
Environmental Exposure - adverse effects
Environmental Exposure - statistics & numerical data
Ethylene Oxide
Female
Humans
KDM-AA
Male
Middle Aged
NHANES
Nutrition Surveys
phenotypic age
Public Health
United States
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Summary:Population aging is a global concern, with the World Health Organization predicting that by 2030, one in six individuals worldwide will be 60 years or older. Ethylene oxide (EO) is a widely used industrial chemical with potential health risks, including associations with age-related diseases. This study investigates the relationship between EO exposure and biological age acceleration. Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016 were analyzed, including 3,155 participants after exclusions. Blood EO levels were measured using hemoglobin adducts (HbEO). Biological age acceleration was assessed using two methods: Phenotypic Age Acceleration (PhenoAgeAccel) and Klemera-Doubal Method Age Acceleration (KDM-AA). Linear and logistic regression models were applied, adjusting for various covariates, and restricted cubic spline (RCS) regression was used to explore non-linear associations. Higher EO exposure was significantly associated with increased PhenoAgeAccel and KDM-AA across all models. In the continuous model, substantial positive associations were observed (PhenoAgeAccel:  = 0.73,  
ISSN:2296-2565
2296-2565
DOI:10.3389/fpubh.2024.1488558