A Seroepidemiologic Study of Cytomegalovirus Infection: Limited Communicability in a Recruit Training Population

A seroepidemiologic study for cytomegalovirus (CMV) infections was performed on a military base. Four hundred ten (69.7%) of 588 incoming recruits had no detectable (1:2) CMV complement fixation (CF) antibody. Six recruits (1.0%) seroconverted during the 14-week training period. CMV antibody rises w...

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Bibliographic Details
Main Authors: Wenzel,Richard P, McCormick,David P, Beam,Walter E , Jr
Format: Report
Language:English
Subjects:
ANTIBODIES
ANTIGENS
CYTOMEGALOVIRUS
HERPETIC VIRUSES
INFECTIOUS DISEASES
Medicine and Medical Research
POPULATION
SALIVARY GLAND VIRUS
SERODIAGNOSIS
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Summary:A seroepidemiologic study for cytomegalovirus (CMV) infections was performed on a military base. Four hundred ten (69.7%) of 588 incoming recruits had no detectable (1:2) CMV complement fixation (CF) antibody. Six recruits (1.0%) seroconverted during the 14-week training period. CMV antibody rises were not observed in 45 patients with etiologically undiagnosed acute respiratory disease. Similarly, no CMV antibody rises were observed in 93 patients with Australia antigen negative viral hepatitis or in 35 patients with an infectious mononucleosis syndrome (three were monospot negative). One man was hospitalized with a 20-day history of marked generalized malaise and nocturnal diaphoresis and showed a significant CF antibody rise to CMV during hospitalization. All who showed a fourfold rise of CMV antiboyd titers had no initially detectable antibody. These data suggest very intimate contact and limited communicability as characteristics of natural transmission in our adult population. Low levels of CMV CF antibody may offer protection in the uncompromised host. (Author) Pub. as U. S. Naval Medical Field Research Lab. Vol. 22, No. 20.