Elevated Glycosyltransferase Activities in Infected or Traumatized Hosts: Nonspecific Response to Inflammation

Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha sub 2 -fucosyltransferase, and alpha sub 3 -fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized...

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Main Authors: Canonico, P G, Little, J S, Powanda, M C, Bostian, K A, Beisel, W R
Format: Report
Language:English
Subjects:
BACTEREMIA
FEVERS
INFECTIOUS DISEASES
INFLAMMATION
LIVER
Medicine and Medical Research
RATS
REPRINTS
RESPONSE(BIOLOGY)
STREPTOCOCCAL PNEUMONIA
TRANSFERASES
TRAUMA
VIRUS DISEASES
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creator Canonico, P G
Little, J S
Powanda, M C
Bostian, K A
Beisel, W R
description Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha sub 2 -fucosyltransferase, and alpha sub 3 -fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver during inflammatory processes. Serum sialyltransferase became elevated in bacteria-infected or burned rats and sandfly fever-infected humans, but did not correlate with acute-phase serum protein changes. These data suggest that nonparenchymal liver cells, such as macrophages, may contribute substantially to elevated sialyltransferase activity in the circulation during infection and, as such, represent a general host response to infection and tissue trauma. Published in Infection and Immunity, v29 n1 p114-118, Jul 1980.
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Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver during inflammatory processes. Serum sialyltransferase became elevated in bacteria-infected or burned rats and sandfly fever-infected humans, but did not correlate with acute-phase serum protein changes. These data suggest that nonparenchymal liver cells, such as macrophages, may contribute substantially to elevated sialyltransferase activity in the circulation during infection and, as such, represent a general host response to infection and tissue trauma. 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source DTIC Technical Reports
subjects BACTEREMIA
FEVERS
INFECTIOUS DISEASES
INFLAMMATION
LIVER
Medicine and Medical Research
RATS
REPRINTS
RESPONSE(BIOLOGY)
STREPTOCOCCAL PNEUMONIA
TRANSFERASES
TRAUMA
VIRUS DISEASES
title Elevated Glycosyltransferase Activities in Infected or Traumatized Hosts: Nonspecific Response to Inflammation
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