Acute Respiratory Tract Toxicity of the Trichothecene Mycotoxin, T-2 Toxin

The systemic toxicology of trichothecene mycotoxins in a variety of laboratory and farm animals is well documented. Toxicity reports following respiratory exposure, however, are mostly anecdotal. For instance, Ismailson first called attention to toxicosis secondary to mold spore inhalation in a bind...

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Bibliographic Details
Main Authors: Creasia, Donald A, Lambert, Richard J
Format: Report
Language:English
Subjects:
AEROSOL GENERATORS
ANIMALS
COMBUSTION
DRAINAGE
EXPOSURE(PHYSIOLOGY)
FUNGI
HEMORRHAGE
INHALATION
LYMPHOCYTES
MOLDS(FORMS)
Mycotoxins
NOSE(ANATOMY)
NOSES
PHYTOTOXINS
RESPIRATORY DISEASES
RESPIRATORY SYSTEM
SENSES(PHYSIOLOGY)
SIGNS AND SYMPTOMS
SPORES
T-2 Toxin
TOXICITY
Toxicology
TOXINS AND ANTITOXINS
Trichothecenes
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Description
Summary:The systemic toxicology of trichothecene mycotoxins in a variety of laboratory and farm animals is well documented. Toxicity reports following respiratory exposure, however, are mostly anecdotal. For instance, Ismailson first called attention to toxicosis secondary to mold spore inhalation in a binder twine factory. More recently, Forgacs described symptoms of a severe pharyngitis, or burning sensation in the nose accompanied by bloody nasal discharge and a moderate to severe cough in workers that developed stachybotryotoxicosis after inhaling dusts from Stachybotrys-contaminated straw. Ueno reported 100% lethality of five mice 5 days after a 160-minute exposure to 140 ppb of T-2 mycotoxin. However, no information on aerosol generation or aersol characterization was given, and only very limited information on exposure conditions was presented. A report issued in 1983 by the Committee on Protection Against Trichothecene Mycotoxins noted that there was a lack of information on inhalation exposure to trichothecene toxins and recommended that this route of exposure be studied. Keywords: Phytotoxins.